Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult-euthanasia by isoflurane overdose-are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440039 | PMC |
| http://dx.doi.org/10.1177/1179069519837564 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crystallization of nanopore-confined imidazolium ionic liquids probed by temperature-resolved grazing-incidence wide angle X-ray scattering (GIWAXS).
Nanoscale Adv
July 2025
University of Kentucky, Department of Chemical and Materials Engineering 177 F.P. Anderson Tower Lexington Kentucky 40506-0046 USA
The crystallization behavior of ionic liquids (ILs) 1-butyl-3-methylimidazolium [BMIM] hexafluorophosphate [PF] and chloride [Cl] is investigated upon confinement in 2.3 or 8.2 nm diameter silica nanopore arrays, along with the effects of covalently modifying the pore walls with 1-(3-trimethoxysilylpropyl)3-methylimidazolium [TMS-MIM] groups.
View Article and Find Full Text PDFInvestigating the effects of chelating agents, surfactants and magnesium cations on the size of LPS aggregates in formulations causing low endotoxin recovery in limulus amebocyte lysate assays.
Eur J Pharm Biopharm
September 2025
Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, United Kingdom. Electronic address:
To ensure safety, pharmaceuticals are rigorously tested for lipopolysaccharide (LPS) contamination, as this can trigger severe immune reactions in patients. Low Endotoxin Recovery (LER), describing the masking of spiked LPS controls in Limulus Amebocyte Lysate (LAL) assays, has been associated with the presence of chelating agents and surfactants in pharmaceutical formulations. The addition of excipients, such as Mg2, have shown the ability to mitigate the effects of LER, however, inconsistencies in various studies regarding the influence of the excipients on LPS aggregate characteristics and LER occurrence hinder a clear understanding of the mechanisms underlying LER.
View Article and Find Full Text PDFLangmuir-Blodgett Films of Conjugated Polymer and Silver Nanoparticles: A Possible Substrate for Pesticide SERS-Based Detection.
Langmuir
September 2025
Federal University of São Paulo, Laboratory of Hybrid Materials, Diadema, São Paulo 09913-030, Brazil.
This study demonstrates the successful fabrication of nanostructured Langmuir-Blodgett (LB) films combining the conjugated copolymer poly(9,9-dioctylfluorene--3,4-ethylenedioxythiophene) (PDOF--PEDOT) with spherical and triangular silver nanoparticles (AgNP). The LB technique allowed precise control over the molecular arrangement and distribution of the nanoparticles at the air-water interface, resulting in compact, reproducible and structurally ordered nanocomposite films. The structural and morphological properties of the interfacial monolayers and LB films were investigated using surface pressure-area isotherms, Brewster angle microscopy, polarization modulation infrared reflection-absorption spectroscopy (PM-IRRAS) and quartz crystal microbalance.
View Article and Find Full Text PDFTunable Aggregate Morphologies from Perfluorodecanoic Acid and Hydroxyalkylamines: Role of Amine Architecture in Fluorocarbon-Hydrocarbon Self-Assembly.
Langmuir
September 2025
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, People's Republic of China.
The study of the self-assembly of surfactants in aqueous solutions, though a traditional field, remains fascinating and full of novelty. In this article, the anionic perfluorodecanoic acid surfactant (PFA) is separately complexed with three hydroxyalkylamines (monoethanolamine (MEA), diethylamine (DEA), and triethanolamine (TEA)) in aqueous solutions. The transformation of aggregate morphologies from spherical unilamellar to nanotubes and then to spherical bilamellar is observed at room temperature, which is confirmed by cryo-transmission electron microscopy (cryo-TEM).
View Article and Find Full Text PDFEffect of C-Terminal Residue on the Phase Behavior and Properties of β-Sheet Forming Self-Assembling Peptide Hydrogels.
Biomacromolecules
September 2025
Division of Pharmacy and Optometry, Manchester Institute of Biotechnology, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, M13 9PL Manchester, U.K.
This study investigates how hydrophobic and hydrophilic modifications at the C-terminus of the base peptide, KFEFEFKFK (KbpK), affect the hydrogel macroscopic properties. By the incorporation of phenylalanine (F, hydrophobic) and lysine (K, hydrophilic) residues, four variants, KbpK-K, KbpK-F, KbpK-KF, and KbpK-FK, were designed and evaluated. pH-concentration phase diagrams and Fourier transform infrared confirmed clear links showing how peptide hydrophobicity and charge influence β-sheet formation and macroscopic phase behavior.
View Article and Find Full Text PDF