Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, , has a broad geographical range across Southeast Asia, India and southern China, however, little is known about their involvement in virus transmission. Here we investigate the diversity and abundance of viral communities from a colony of residing in Singapore. Our results detected 47 and 22 different virus families from bat fecal and urine samples, respectively. Among these, we identify a large number of virus families including and In most cases, viral sequences from are genetically related to a group of bat viruses from other bat genera (e.g., , , and ). The results of this study improve our knowledge of the host range, spread and evolution of several important viral pathogens. More significantly, our findings provide a baseline to study the temporal patterns of virus shedding and how they correlate with bat phenological trends.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466414PMC
http://dx.doi.org/10.3390/v11030250DOI Listing

Publication Analysis

Top Keywords

evolution viral
8
cave nectar
8
virus families
8
bat
6
viral
5
diversity evolution
4
viral pathogen
4
pathogen community
4
community cave
4
nectar bats
4

Similar Publications

Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.

Sci Transl Med

September 2025

Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Human B cell immunity to the influenza hemagglutinin (HA) stem, a universal vaccine target, is often stereotyped and immunogenetically restricted, posing hurdles to study outside of humans. Here, we show that cynomolgus macaques vaccinated with an HA stem immunogen elicit humanlike public B cell lineages targeting two major conserved sites of vulnerability, the central stem and anchor epitopes. Central stem antibodies were predominantly derived from V1-138, the macaque homolog of human V1-69, a V gene preferentially used in human central stem broadly neutralizing antibodies (bnAbs).

View Article and Find Full Text PDF

Kobuviruses (family Picornaviridae, genus Kobuvirus) are enteric viruses that infect a wide range of both human and animal hosts. Much of the evolutionary history of kobuviruses remains elusive, largely due to limited screening in wildlife. Bats have been implicated as major sources of virulent zoonoses, including coronaviruses, henipaviruses, lyssaviruses, and filoviruses, though much of the bat virome still remains uncharacterized.

View Article and Find Full Text PDF

Identification and Molecular Characterization of Two Novel Picorna-Like Viruses in Mosquitoes in Yunnan, China.

Vector Borne Zoonotic Dis

September 2025

Yunnan Province Key Laboratory of Public Health and Biosafety, Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, School of Public Health, Kunming Medical University, Kunming, P.R. China.

: Mosquitoes harbor diverse insect-specific viruses (ISVs) frequently overlooked in arbovirus surveillance. Comprehensive characterization of ISVs is crucial for understanding their impact on host ecology and potential roles in arbovirus transmission. : Using metagenomic sequencing on Armigeres subalbatus from Yunnan, China, we identified two novel picorna-like viruses, assembled their genomes, and conducted phylogenetic analysis.

View Article and Find Full Text PDF

Deltaviruses are subviral agents of animals, which, in humans, require a hepadnavirus helper for transmission. The absence of deltavirus-like endogenous viral elements (δEVEs) has prevented an understanding of their evolution in deep time. By screening the representative genomes of all metazoans for endogenous delta antigen-like sequences, we report the discovery of 13 δEVEs in the genomes of five species of termites.

View Article and Find Full Text PDF

Arenaviruses and Hantaviruses, primarily hosted by rodents and shrews, represent significant public health threats due to their potential for zoonotic spillover into human populations. Despite their global distribution, the full impact of these viruses on human health remains poorly understood, particularly in regions like Africa, where data is sparse. Both virus families continue to emerge, with pathogen evolution and spillover driven by anthropogenic factors such as land use change, climate change, and biodiversity loss.

View Article and Find Full Text PDF