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Background: Jugular foramen tumors, particularly those that are triple dumbbell-shaped with intracranial, intraforaminal, and extracranial extensions, are difficult to access surgically. However, advances in neuroimaging, neuromonitoring, and skull base surgery have enabled their safe resection with lower rates of morbidity and mortality.
Method: We share our experience with the surgical technique for the management of triple dumbbell-shaped jugular foramen schwannomas.
Conclusion: The infralabyrinthine transjugular transsigmoid approach with high cervical exposure under continuous vagus nerve monitoring enables gross total resection of triple dumbbell-shaped jugular foramen schwannomas, aiming at surgical cure of these benign tumors for appropriately selected patients.
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http://dx.doi.org/10.1007/s00701-019-03860-1 | DOI Listing |
ACS Appl Mater Interfaces
May 2025
State Key Laboratory of Radio Frequency Heterogeneous Integration (Shenzhen University), College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China.
While nanozyme-mediated catalytic therapy holds promise for precision oncology, achieving spatiotemporal control over enzymatic activity and synergistic therapeutic amplification in the biologically favorable second near-infrared window (NIR-II) remains an unmet challenge. In this study, we present a breakthrough in plasmonic heterojunction engineering through the rational design of asymmetric dumbbell-shaped Au nanorod@end-mesoporous Pd architectures that establish a high density of plasmonic hotspots at the mesopore sites. Unlike conventional core-shell configurations (Au@mesoPd) showing negligible NIR-II response, our heterostructure demonstrates a nearly 200% enhancement in peroxidase-like activity under 1064 nm excitation through precisely engineered hot electron dynamics.
View Article and Find Full Text PDFTalanta
August 2025
School of Public Health &Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330031, PR China. Electronic address:
Rapid and sensitive detection of specific RNA sequences is crucial for clinical diagnosis, surveillance, and biotechnology applications. Currently, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is the gold standard for RNA detection; however, it is associated with long processing time, complex procedures, and a high false-positive rate. To address these challenges, we developed a novel sensing platform based on CRISPR/Cas13a that incorporates a dumbbell-shaped hairpin and DNA-PAINT for rapid, highly specific, and sensitive RNA analysis.
View Article and Find Full Text PDFFront Oncol
October 2024
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The surgical management of extensive jugular foramen schwannomas presents a formidable challenge, aiming for gross total resection while minimizing complications. Here, we present a case with giant triple dumbbell-shaped jugular Foramen Schwannoma. A 45-year-old male with a one-year history of a left neck mass underwent surgery.
View Article and Find Full Text PDFAnal Chem
October 2024
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.
Accurate monitoring of base excision repair (BER) activity in cancer cells is critical for advancing the comprehension of DNA repair processes, gaining insights into cancer development, and guiding treatment strategies. However, current assay techniques for assessing BER activity in cancer cells face challenges due to the heterogeneous origins and diversity of BER enzymes. In this work, we present a hihly relible riple loop-intrlocked DNA coec (GATED) that enables precise assessment of BER activity in cancer cells through signal amplification mediated by multienzyme orthogonal activation.
View Article and Find Full Text PDFChemistry
August 2020
Group for Molecular Engineering of Functional Materials, EPFL VALAIS, 1951, Sion, Switzerland.
Three novel donor-π-bridge-donor (D-π-D) hole-transporting materials (HTMs) featuring triazatruxene electron-donating units bridged by different 3,4-ethylenedioxythiophene (EDOT) π-conjugated linkers have been synthesized, characterized, and implemented in mesoporous perovskite solar cells (PSCs). The optoelectronic properties of the new dumbbell-shaped derivatives (DTTXs) are highly influenced by the chemical structure of the EDOT-based linker. Red-shifted absorption and emission and a stronger donor ability were observed in passing from DTTX-1 to DTTX-2 due to the extended π-conjugation.
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