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| http://dx.doi.org/10.1016/j.tim.2019.02.001 | DOI Listing |
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Article Synopsis
- Bacterial adhesins play a crucial role in helping bacteria stick to surfaces for colonization, with specific ligand-binding domains at the end of long molecules.
- Researchers utilized AlphaFold2 to model these large proteins, confirming that certain structural features distinguish ligand-binding domains from other types.
- Identifying the ligands these domains attach to could lead to new strategies for preventing bacterial infections, and modifying these binding domains may change the surfaces bacteria can adhere to.