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The purpose of this study was to determine the antidiabetic effect of an extract of nutricultured containing vanadium (BECV). The BECV was prepared following nutriculture of with a Jeju water vanadium concentrate for 7 day. The BECV was administered to mice for 8 weeks at different dosages (0.028, 0.14, and 0.7 μg/kg; as vanadium concentration in BECV). After 8 weeks, the BECV results showed mouse blood glucose concentrations to significantly decrease, in a dose-dependent manner, compared with the results for control mice. In addition, the concentrations of triglyceride, total cholesterol, and glycated hemoglobin were significantly lower after 8 weeks of administration of 0.7 μg/kg BECV. Therefore, the BECV may have protective effects against type 2 diabetes.
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http://dx.doi.org/10.1007/s10068-018-0436-8 | DOI Listing |
Food Chem
August 2025
Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai, India.
Coextraction of Citrullus lanatus seeds and Citrus aurantium peels (1:1, w/w), two food processing wastes, was performed using supercritical carbon dioxide (scCO) (345 bar|57 °C|178 min) and pet ether solvents. The major objective of the study was to valorize two fruit processing wastes to obtain a bioactive coextract using a green scCO extraction process and further incorporate it into wax-based composite oleofoams. The scCO coextraction resulted in better extraction of bioactive compounds such as d-limonene and polyunsaturated fatty acids due to the absence of light and lower temperature of extraction, compared to pet ether.
View Article and Find Full Text PDFFood Sci Nutr
September 2025
Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty Selcuk University Konya Turkey.
The current investigation was designed to explore the chemical composition, antioxidant capacity, enzyme inhibitory activity, and cytotoxic potential of four different extracts (Ethyl Acetate, Ethanol, Ethanol/Water (70%) and Water) derived from the aerial parts of . In vitro, assessments were performed utilizing diverse antioxidant assays, along with evaluations of neuroprotective enzyme inhibition targeting acetylcholine and butyl choline enzymes, as well as antidiabetic activities against α-amylase and α-glucosidase and a potential candidate for a tyrosinase inhibitor. LC-ESI-QTOF-MS identification provided a total of 70 compounds in the extracted samples of , including kaempferol 3-(deoxyhexosyl-hexoside)-7-hexoside, rutin, quercetin dideoxyhexoside, caffeic acid hexoside, quinoline alkaloids, morphine derivatives, and scoulerine.
View Article and Find Full Text PDFCureus
August 2025
Department of Medicine, Bangladesh Institute of Health Sciences (BIHS) General Hospital, Dhaka, BGD.
Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder frequently associated with obesity, leading to increased risks of cardiovascular and renal complications. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has emerged as a promising therapeutic agent for improving glycemic control and promoting weight reduction. However, evaluating its safety and efficacy in obese T2DM patients remains essential, particularly in real-world clinical settings.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Heilongjiang Provincial Hospital, Harbin, China. Electronic address:
Polygonatum odoratum polysaccharides (POPs) are the key bioactive components of Polygonatum odoratum (Mill.) Druce, a medicinal and edible plant with over two millennia of documented use in traditional Chinese medicine. POPs exhibit a wide range of pharmacological activities, such as hypoglycemic, antioxidant, immunomodulatory, antitumor, hepatoprotective, and gut microbiota-modulation effects.
View Article and Find Full Text PDFPlanta Med
September 2025
Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
Various species have been traditionally used to treat diabetes; however, the antidiabetic potential and safety of many of these species remain poorly understood. This study evaluated the chemical composition, antihyperglycemic activity, insulin-sensitizing effect, and acute oral toxicity of . Dichloromethane, ethyl acetate, -butanol, and aqueous residue fractions were obtained via liquid-liquid extraction from the hydroalcoholic extract obtained via maceration of the aerial parts.
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