Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The application of MCM-41 functionalized by 12-tungstophosphoric acid (TPA) as drug carrier for cancer treatment was studied by loading of camptothecin (CPT). In-vitro controlled release study of CPT in Simulated Body Fluid (pH 7.4, 37 °C) was carried out under stirring as well as static conditions. The systems were also evaluated on cancer cells (HepG2) and the carriers are found to be non-toxic to the cancer cells. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with CPT loaded unfunctionalized MCM-41. A detailed study on release kinetics and release mechanism using First Order Release Kinetic Model, Higuchi Model, Koresmeyer-Pepps Model and Extended kinetic model was also carried out.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.msec.2019.01.065 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Short-Course Antibiotic Agent Therapy for Early Ventilator-Associated Pneumonia in Patients with Trauma.
Surg Infect (Larchmt)
September 2025
Department of Surgery, Division of Acute Care Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Patients with traumatic injuries who develop ventilator-associated pneumonia (VAP) incur a higher risk of developing multi-drug resistance. Shorter duration of antibiotic agents for early VAP at five days may reduce antibiotic agent exposure without worsening patient outcomes. This retrospective cohort study performed at a Level I Trauma Center included adult (≥16 years old) patients with trauma diagnosed with bronchoalveolar lavage (BAL)-proven early (within four days of intubation) bacterial VAP.
View Article and Find Full Text PDF[Impact of the «ELADEB» tool and a case manager for hospitalized patients with complex care].
Rev Med Liege
September 2025
Service de psychologie clinique et d'action sociale, ULiège, Belgique.
Patients with complex care needs present numerous challenges: the care they receive is often associated with more hospital admissions. The care provided to this group could benefit from being more goal-oriented and better integrated. However, strengthening a net-work of care for these patients starting from hospitalization remains a challenge.
View Article and Find Full Text PDF14-3-3 Proteins Negatively Regulate Microglial Activation via Inhibition of the NF-κB Pathway.
J Neurochem
September 2025
Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Microglia, the resident immune cells of the central nervous system (CNS), are involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD), Dementia with Lewy Bodies (DLB), and Parkinson's disease (PD). 14-3-3 proteins act as molecular hubs to regulate protein-protein interactions, which are involved in numerous cellular functions, including cellular signaling, protein folding, and apoptosis. We previously revealed decreased 14-3-3 levels in the brains of human subjects with neurodegenerative diseases.
View Article and Find Full Text PDFCovalently Supported Phenazine for Electrochemical Capture of Low Concentration CO.
ACS Appl Mater Interfaces
September 2025
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.
Electrochemical CO capture (eCC) excels in selectivity, reversibility, low-temperature operation, and reusability, yet liquid-phase systems struggle with mass transfer limitations. In this study, a phenazine-based capture agent was chemically grafted onto carboxylated carbon nanotubes, achieving an active loading of 4.4 wt %.
View Article and Find Full Text PDFTrends and Disparities in Poststroke Depression Within 1 Year of Ischemic Stroke.
J Neuropsychiatry Clin Neurosci
September 2025
Departments of Radiology, Neurology, and Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Objective: One of the most frequent neuropsychiatric complications after a stroke is poststroke depression (PSD). However, it is unclear whether disparities exist in PSD diagnosis. The authors examined a 10-year trend in PSD by socioeconomic and clinical characteristics.
View Article and Find Full Text PDF