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http://dx.doi.org/10.1093/jac/dkz047 | DOI Listing |
Cell Biochem Biophys
September 2025
Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, 34003, Türkiye, Turkey.
Vitamin B12 is a vital water-soluble vitamin containing a central cobalt atom within its corrin ring structure. It exists in several derivatives, among which methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl) are the biologically active forms that serve as cofactors in essential enzymatic reactions. Although the neurological and hematological consequences of vitamin B12 deficiency have been extensively studied, its role in immune regulation remains less well understood.
View Article and Find Full Text PDFCureus
August 2025
Health and Mental Hygiene, New York City Poison Control Center, New York, USA.
Salicylate toxicity usually occurs as a result of elevated serum salicylate concentrations. Salicylate concentrations can be measured in cerebrospinal fluid (CSF), but the interpretation of these values is less well understood. Two phenomena believed to be associated with salicylate toxicity are neuroglycopenia and salicylate-induced coagulopathy, but these cases are typically not well-characterized.
View Article and Find Full Text PDFACS Sens
September 2025
Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi 530021, China.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by cognitive decline and behavioral impairments, typically manifesting in the elderly and presenile population. With the rapid global aging trend, early diagnosis and treatment of AD have become increasingly urgent research priorities. The primary pathological features of AD include excessive accumulation of β-amyloid (Aβ) plaques, the formation of neurofibrillary tangles, and neuronal loss.
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September 2025
Global Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd.Tokodai 5-1-3, Tsukuba, Ibaraki 300-2635, Japan.
Irsenontrine is a novel phosphodiesterase-9 inhibitor that has been developed for the treatment of cognitive dysfunction. To assess the pharmacokinetics, excretion, and distribution of the drug in humans, comprehensive assays for irsenontrine were developed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) in three human matrices, including plasma, urine, and cerebrospinal fluid (CSF). Irsenontrine was extracted from the matrices by a straightforward protein precipitation method and subsequently separated on a reverse-phase column.
View Article and Find Full Text PDFNeuroimage
September 2025
Developing Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences,
The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T-weighted brain images and MRS data were acquired in the cerebellum, right frontal lobe and basal ganglia.
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