Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aim: To evaluate the effect of exenatide long acting release (LAR) on carotid intima-media thickness (IMT) and endothelial function in patients with type 2 diabetes mellitus.
Methods: Sixty subjects with type 2 diabetes mellitus were treated with exenatide LAR as add-on to stable doses of metformin for 8 months in an open label study. Anthropometric variables, lipid profile and glycemic parameters were assessed by routine analysis. Carotid IMT by Doppler ultrasound and endothelial function by flow-mediated dilation of the brachial artery were also assessed.
Results: Exenatide significantly improved fasting glycaemia (from 8.8 ± 2.8 to 7.3 ± 2.2 mmol/L, p < 0.0001), HbA1c (from 8.0 ± 0.4 to 6.9 ± 1.1%, p < 0.0001), body mass index (from 33 ± 9 to 31 ± 6 kg/m, p = 0.0348) and waist circumference (from 109 ± 13 to 106 ± 13 cm, p = 0.0105). There was a significant improvement of the lipid profile, except in triglyceride level where no changes were observed. Carotid IMT and flow-mediated dilation were also improved (from 0.98 ± 0.14 to 0.87 ± 0.15 mm and from 5.8 ± 1.3 to 6.8 ± 1.7%, respectively; p < 0.0001 for both).
Conclusions: Treatment with exenatide LAR led to improved cardio-metabolic parameters, including carotid IMT and flow-mediated dilation, independently of glucometabolic control. These results may help to explain, at least in part, the cardiovascular safety of exenatide LAR, as recently reported in cardiovascular outcome trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.diabres.2019.02.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiovascular Assessments in Children and Adolescents With Hypertension.
Rev Cardiovasc Med
August 2025
Department of Nephrology, Akron Nephrology Associates at Cleveland Clinic Akron General Medical Center, Akron, OH 44302, USA.
Cardiovascular assessments in children and adolescents with hypertension are essential for detecting early signs of organ damage and guiding timely interventions. The pathophysiology of pediatric hypertension involves a complex interplay of arterial stiffness, endothelial dysfunction, metabolic disturbances, activation of the renin-angiotensin-aldosterone system, and immune dysregulation. These mechanisms collectively contribute to target organ damage, particularly in the cardiovascular system.
View Article and Find Full Text PDFAssociation of cardiovascular risks and carotid stiffening at ultrafast ultrasound imaging in young populations.
Eur Radiol
September 2025
Department of Ultrasound, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Objectives: To evaluate the predictive role of carotid stiffening, quantified using ultrafast pulse wave velocity (ufPWV), for assessing cardiovascular risk in young populations with no or elevated cardiovascular risk factors (CVRFs).
Materials And Methods: This study enrolled 180 young, apparently healthy individuals who underwent ufPWV measurements. They were classified into three groups: the CVRF-free group (n = 60), comprising current non-smokers with untreated blood pressure < 140/90 mmHg, fasting blood glucose (FBG) < 7.
Association Between the Vascular Ageing of the Carotid Arteries and Different Dialysis Modalities.
Cureus
August 2025
Center for Clinical Pharmacology, Medical Faculty of Military Medical Academy, Belgrade, SRB.
Background Chronic kidney disease is a major global health problem, significantly increasing the risk of cardiovascular complications compared to the general population. This study aimed to evaluate vascular aging in patients with end-stage renal disease treated with hemodialysis or peritoneal dialysis by analyzing clinical and laboratory parameters and carotid intima-media thickness (CIMT), with the goal of identifying predictors of carotid disease and comparing the prevalence between groups. Methods We conducted a retrospective cohort study that included 59 subjects with end-stage renal disease who were treated with renal replacement therapy: peritoneal dialysis (29 subjects) and hemodialysis (30 subjects).
View Article and Find Full Text PDFThe Association of Premature Atherosclerosis with Ischemic Stroke in Young People with HIV in Lusaka, Zambia.
J Stroke Cerebrovasc Dis
September 2025
Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Background: Premature atherosclerosis has been observed among people with HIV (PWH) with high risk of cerebrovascular disease. The aim of this study was to evaluate premature atherosclerosis in young PWH with and without ischemic stroke.
Methods: We conducted a prospective case-control study at the University Teaching Hospital in Lusaka, Zambia between March 2022 and October 2024, comparing young PWH with non-cardioembolic ischemic stroke (cases) with PWH without a history of stroke (controls) matched (1:2) for age, sex and race.
Rotating shift work, with night shift work, affects cardiovascular risk factors: a 6-year follow-up study in the insulation industry.
Occup Environ Med
September 2025
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Objectives: To assess absolute levels and longitudinal changes in cardiovascular disease (CVD) risk factors over 6 years among rotating shift workers with night shift work and day workers in industry.
Methods: We studied three groups, 32 night shift workers in Plant A with a high night load, 23 in Plant B with a low night load and 25 day workers during a 6-year follow-up (FU). We collected demographics by questionnaire, measured blood pressure, resting heart rate, carotid intima-media thickness (cIMT), carotid to femoral pulse wave velocity (cfPWV) and maximal oxygen uptake (V̇O).