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This study examined the mediating role of maternal unsupportive parenting in explaining associations between family instability and children's externalizing symptoms during the transition to formal schooling in early childhood. Participants included 243 preschool children (M age = 4.60 years) and their parents. Findings from cross-lagged autoregressive models conducted with multimethod (survey and observations), multi-informant (parent, teacher, and observer), longitudinal (three annual waves of data collection) data indicated that experiences with heightened family instability predicted decreases in supportive parenting, which in turn predicted increases in children's externalizing symptoms. Analyses also revealed a bidirectional association between parenting and family instability over time, such that higher levels of instability predicted decreases in supportive parenting, which in turn predicted increases in family instability.
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http://dx.doi.org/10.1017/S0954579418001736 | DOI Listing |
SAGE Open Nurs
September 2025
Faculty of Health Professions, Al-Quds University, Abu Dies, Palestine.
Introduction: Blood supply shortages remain a pressing global health issue, particularly in resource-limited regions. The West Bank region in Palestine, characterized by frequent conflicts and instability, faces additional challenges due to its fragile healthcare system, where a substantial proportion of blood donations still relies on family-replacement donors rather than voluntary donations.
Objective: This study examines changes in knowledge, attitudes, and practices (KAP) related to blood donation among Palestinians from 2022 to 2025, aiming to guide strategies for a sustainable voluntary donation system.
Curr Gene Ther
August 2025
State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing 100191, China.
Cerebral Cavernous Malformations (CCMs) are vascular anomalies in the central nervous system that arise from both genetic and non-genetic factors, and can cause hemorrhage, seizures, and neurological deficits. Approximately 80% of CCMs are sporadic, while 20% are Familial (FCCMs), an autosomal dominant, monogenic disorder characterized by multiple lesions and severe clinical manifestations. Over the past three decades, linkage analyses have identified KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3 as major pathogenic genes in FCCMs.
View Article and Find Full Text PDFAcad Pediatr
September 2025
Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Safe and stable housing is foundational for child and adolescent health; likewise, housing instability and homelessness are associated with significant pediatric health risk. This narrative review sought to: (1) describe the impact of stable housing, housing instability, and homelessness on child and adolescent health, and (2) explore advocacy interventions for pediatricians to support unstably housed children, youth and families. While the relationship between health and housing is complex, here, we describe three primary mechanisms through which housing impacts pediatric health.
View Article and Find Full Text PDFCell Rep
September 2025
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pôle de Recherches Sino-Français en Science du Vivant et Gé
RNA helicase DDX3X is generally implicated in inflammasome activation and anti-viral responses. We characterize the common features of scattered DDX3X mutations in lymphoid cancers using molecular dynamics simulation and crystallization, thereby demonstrating their crucial role in Epstein-Barr virus (EBV) lytic gene-driven oncogenic processes. The DDX3X mutation is significantly related to impaired stimulator of interferon genes (STING)/ interferon regulatory factor 7 (IRF-7)/interferon (IFN)-α/β-mediated innate immunity, overexpression of EBV lytic gene BNLF2b, and increased formation of R-loops.
View Article and Find Full Text PDFPLOS Glob Public Health
September 2025
Center for Tuberculosis, Institute for Global Health Sciences, University of California San Francisco, San Francisco, California, United States of America.
Multi-month dispensing of tuberculosis (TB) drugs is an innovative strategy that may reduce frequent clinic visits and travel costs among people with TB (PWTB) in rural areas. To inform a planned trial, we explored the appropriateness, barriers, and facilitators to multi-month dispensing among PWTB and healthcare providers in rural eastern Uganda. We used qualitative methods situated within the Consolidated Framework for Implementation Research to explore two refill schedules for multi-month dispensing of TB drugs-a four- or five-visit refill schedule.
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