Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study was conducted to compare the efficacy of clozapine vs. risperidone in the treatment of aggression in conduct disorder in children and adolescents.
Methods: Twenty-four children with conduct disorder aged 6 to 16 years were randomized in a prospective, double-blind trial into two groups to receive clozapine or risperidone for 16 weeks. The Modified Overt Aggression Scale score was used as the primary outcome of the study. Secondary outcomes were Child Behavior Checklist (CBCL) externalization (CBCL-E) and internalization factors; Aggression, Hyperactivity and Delinquency subscales of CBCL-E, Child Global Assessment Scale (CGAS), Barnes Akathisia Rating Scale, and Simpson-Angus Scale.
Results: Both antipsychotics were similarly effective in the primary outcome and in most of the secondary ones. Clozapine was more effective in CBCL-E, the delinquency subscale and the CGAS scores than risperidone ( =0.039, 0.010, and 0.021). Two subjects from the clozapine group were excluded due to a low neutrophil count at week four.
Conclusion: Clozapine and risperidone are effective for short-term treatment of aggression in children and adolescents with conduct disorder. Clozapine was more effective than risperidone in conduct externalization factors, delinquency trait and global functioning in children and adolescents. Stronger efficacy of clozapine should be investigated in larger sample sizes using pharmacogenomic studies. White blood cell counts need to be monitored when prescribing clozapine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361039 | PMC |
| http://dx.doi.org/10.9758/cpn.2019.17.1.43 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Appetite measures as correlates of clinical response in mood disorders treated with ketamine: systematic review.
Front Nutr
August 2025
Faculty of Medicine, Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland.
Unlabelled: Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BP), significantly impact global health, with MDD affecting over 300 million people and BP affecting approximately 2% of the world's population. Ketamine, originally an anesthetic, has emerged as a promising treatment for patients with treatment-resistant depression (TRD), due to its unique pharmacological properties, such as N-methyl-D-aspartate (NMDA) receptor antagonism and anti-inflammatory effects. The potential of ketamine in treating depression has sparked debate regarding its effects on appetite.
View Article and Find Full Text PDFDirectional associations between antisocial behavior and alcohol use disorder symptoms from adolescence through adulthood: A sibling comparison cross-lagged approach.
Alcohol Clin Exp Res (Hoboken)
September 2025
University of California San Diego, La Jolla, California, USA.
Background: A well-established link between antisocial behavior (ASB) and problematic alcohol use in adolescence has been demonstrated, yet the direction of this association across the lifespan remains unclear. Although antisocial conduct may increase exposure to known social and environmental risk factors for developing alcohol use disorder (AUD), alcohol use may also impair social functioning and self-regulation that subsequently increases ASB risk. Using a sibling comparison design in a high-risk sample, this study tested bidirectional associations between symptom counts of ASB and AUD from adolescence through adulthood.
View Article and Find Full Text PDFShared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction.
Brain Behav
September 2025
Pontificia Universidad Javeriana, Facultad De Ciencias, Departamento de Biología, Biología de Plantas y Sistemas Productivos, Bogotá, Colombia.
Introduction: The study explores shared genetic architecture among major psychiatric disorders-major depressive disorder, bipolar disorder, schizophrenia, and post-traumatic stress disorder-emphasizing their overlapping molecular pathways. Using public datasets, we identified shared genes and examined their functional implications through protein-protein interaction (PPI) networks and gene set enrichment analysis (GSEA).
Methods: Genes associated with each disorder were identified through the NCBI Gene database.
The Dino Study: Rationale and protocol for a randomized controlled trial of the Incredible Years Dinosaur Program with daily assessments.
PLoS One
September 2025
Department of Developmental Psychology, Tilburg University, Tilburg, The Netherlands.
Background: Children with conduct problems vary considerably in how they respond to behavioral interventions. Although group-based, child-focused programs are increasingly implemented, research still relies on retrospective parent or teacher reports and group-level outcomes. These traditional approaches often obscure individual differences in treatment response and reduce the potential for individualized behavioral support tailored to each child's unique profile.
View Article and Find Full Text PDFCost-Effectiveness of Treatment for Opioid Use Disorder in Pregnancy and Its Impact on Birth Outcomes.
JAMA Pediatr
September 2025
Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Importance: For the first time in nearly 2 decades, the US infant mortality rate has increased, coinciding with a rise in overdose-related deaths as a leading cause of pregnancy-associated mortality in some states. Prematurity and low birth weight-often linked to opioid use in pregnancy-are major contributors.
Objective: To assess the health and economic impact of perinatal opioid use disorder (OUD) treatment on maternal and postpartum health, infant health in the first year of life, and infant long-term health.