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Floods may influence different types of diarrheal diseases and epidemiological studies of pathogen-specific diarrhea due to floods in China are still needed. In addition, few studies have been conducted to quantify the lag and cumulative risk of diarrheal disease due to floods in Guangxi, China. Our study aimed to identify different types of diarrheal diseases that were sensitive to floods and to quantify their lag and cumulative impact. A matched analysis based on time series data of floods and infectious disease from 2006 to 2010 was conducted in Guangxi, China. Each flood day was treated as an independent unit in our study. A simplified assumption that each day of the flood confers the same risk was adopted before analysis. Each flood day was matched to a non-flood day by city and time. Log-linear mixed-effects regression models were used to quantify the association between different types of diarrheal diseases and floods. Lag and cumulative effects were also calculated to get delayed and overall effects. A total of 45,131 diarrhea cases were notified in the study area over the study period. After controlling for the long-term trend, seasonality, and meteorological factors, floods caused a significantly increased risk of total diarrheal diseases. The RR was highest at lag 2 days (RR=1.24, 95% CI: 1.11-1.40). Floods caused a significantly increased risk in bacillary dysentery and in other infectious diarrhea, but not in typhoid fever and paratyphoid fever. Floods were significantly associated with total diarrheal diseases and other infectious diarrhea for both cumulative lag 0-7 and 0-14 days. Our study provides strong evidence of a positive association between floods and diarrheal diseases including bacillary dysentery and other infectious diarrhea in study area. Public health interventions should be taken to prevent a potential risk of these flood-sensitive diarrheal diseases according to the different lag period after floods.
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http://dx.doi.org/10.1016/j.envres.2018.12.067 | DOI Listing |
J Infect Public Health
August 2025
Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, UK. Electronic address:
Nipah virus (NiV) has emerged as a significant public health threat, with recurring outbreaks in Bangladesh often linked to the consumption of raw date palm sap contaminated by fruit bats (Pteropus species). Over the past two decades, substantial efforts have been made to understand the cultural context of sap consumption, promoting behavior change and developing interventions to prevent NiV spillover. Despite these efforts, achieving sustainable change in sap consumption practices remains challenging due to deep-seated cultural practices, community perceptions of sap consumption, habitual behaviors, limited awareness of health risks and economic barriers.
View Article and Find Full Text PDFAnaerobe
September 2025
Department of Microbiology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan; Clinical and Research Center for Infectious Diseases, Toyama University Hospital, Toyama, Japan; Center for Advanced Antibody Drug Development, University of Toyama, Toyama, Japan. Electronic add
Objectives: Clostridioides difficile infection (CDI) is a well-known healthcare-associated diarrheal disease. Fidaxomicin, a key antibiotic used to treat CDI, targets bacterial RNA polymerase. However, some clinical isolates have mutations in rpoB, which reduces their susceptibility to this antibiotic.
View Article and Find Full Text PDFFront Microbiol
August 2025
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Porcine rotavirus (PoRV) is one of the major pathogens causing viral enteritis in piglets, posing serious threats to the pig industry and public health. Existing pathogen detection methods, such as RT-qPCR, suffer from complex procedures and strong reliance on equipment, making them difficult to meet the needs of grassroots laboratories or field detection. Therefore, in this study, a novel rapid and visual detection platform, was developed based on the CRISPR/Cas13 system.
View Article and Find Full Text PDFClin Infect Dis
September 2025
Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA.
Background: Approximately 1.5 billion doses of novel oral polio vaccine type 2 (nOPV2) have been administered in response to circulating vaccine-derived poliovirus type 2 (cVDPV2) outbreaks since 2021. Although infants are eligible to receive the vaccine from birth, the induction of intestinal mucosal immunity by nOPV2 in newborns has not been directly evaluated.
View Article and Find Full Text PDFPaediatr Perinat Epidemiol
September 2025
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Background: Studies of child mortality that employ minimally invasive tissue sampling (MITS) produce highly accurate cause of death data; however, selection bias may render these as non-representative of their underlying populations.
Objectives: Estimate cause-specific mortality fractions and rates for the five most frequent causes-underlying and others in the chain of events leading to death-among stillbirths, neonatal, infant and child deaths-in Sub-Saharan Africa and South Asia, adjusted for any identified selection biases.
Methods: The Child Health and Mortality Prevention Surveillance (CHAMPS) Network collects standardised, population-based, longitudinal data on causes of death among stillbirths and under-five children in 12 catchments in seven countries in Sub-Saharan Africa and South Asia.