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Objective: To investigate the correlation between life events, coping styles and depression of adolescent in Haikou.
Methods: In the urban and rural areas of Haikou between March and May, 2015, a total of 4995 students from grade 4 to grade 9 of6 primary schools and 6 junior middle schools were selected by stratified cluster sampling. Children's Depression Inventory( CDI), Adolescent Self-Rating Life Events Check List( ASLEC) and Simplified Coping Style Questionnaire( SCSQ) were used for the study. A total of 4866 valid questionnaires were recovered. Among them, there were 2508 boys and2358 girls. The number of primary school students was 2670, and the number of juniormiddle school students was 2196. There were 3385 urban students and 1481 rural students.
Results: The detection rate of depressive symptoms was 32. 3%( 1573/4866). The total score of ASLEC( 71. 14 ± 22. 79 vs. 57. 87 ± 20. 73) and interpersonal relationships( 3. 21 ± 1. 08 vs. 2. 67 ± 0. 96), study pressure( 3. 00 ± 1. 00 vs. 2. 50 ±0. 91), punished( 2. 65 ± 1. 06 vs. 2. 11 ± 0. 96), loss( 2. 57 ± 1. 49 vs. 2. 16 ± 1. 36), health adaptation( 2. 27 ± 1. 10 vs. 1. 93 ± 0. 96) and other dimension( 2. 55 ± 1. 08 vs. 1. 86 ± 0. 88) were higher in students with depressive symptoms than those in normal students, and the difference was statistically significant( P < 0. 001). The positive coping scores of adolescents with depression was( 2. 48 ± 0. 52), while normal adolescents was( 2. 78 ± 0. 55, P < 0. 001). The negative coping score of adolescents with depression was( 2. 28 ± 0. 51), while normal adolescents was( 2. 14 ± 0. 48, t =-9. 49, P < 0. 001). By using Pearson's simple correlation analysis, interpersonal relationships, study pressure, punished, loss, health adaptation and other life events were positively correlated with adolescent depression, the correlation coefficients were 0. 317, 0. 306, 0. 304, 0. 172, 0. 207 and 0. 390, respectively. Pearson's simple correlation analysis of adolescent depression and response showed that the correlation coefficient between adolescent depression and positive coping was-0. 353, and the correlation coefficient of negative coping was 0. 169.
Conclusion: The symptoms of adolescent depression in Haikou City was positively correlated with the life events of adolescents, and negatively correlated with positive coping, and positively correlated with negative coping.
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Turk J Pediatr
September 2025
Department of Public Health, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
Background: The ongoing conflict in Gaza continues to take an unbearable toll, with particularly severe impacts on children. Measuring the burden of conflict-related disease in Gaza in terms of disability-adjusted life years (DALYs) is important in terms of showing this effect. The aim of this study was to calculate the conflict-related DALY in Gaza among children aged 0-14 years, following the October 7 events and compare these values with global and expected values.
View Article and Find Full Text PDFMicrob Genom
September 2025
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan, ROC.
remains a leading respiratory pathogen for children and the elderly. In Taiwan, a national PCV13 catch-up vaccination programme for children began in March 2013. This study investigates the population structure and antimicrobial profiles of pneumococcal isolates in Taiwan from 2006 to 2022.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Ubiquity of cancer across the tree of life yields opportunities to understand variation in cancer defences across species. Peto's paradox, the finding that large-bodied species do not suffer from more cancer despite having more cells at risk of oncogenic mutations compared to small species, can be explained if large size selects for better cancer defences. Since birds live longer than non-flying mammals of equivalent size, and are descendants of moderate-sized dinosaurs, we ask whether ancestral cancer defences are retained if body size shrinks in a lineage.
View Article and Find Full Text PDFPLoS Med
September 2025
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Background: Oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) preexposure prophylaxis (PrEP) effectiveness against HIV acquisition highly depends on adherence. For men who have sex with men, a dosing study in the United States (US) population defined clinically meaningful tenofovir diphosphate (TFV-DP) thresholds in dried blood spots (DBS) based on the rounded 25th percentile for 2, 4, and 7 doses/week as 350, 700, and 1,250 fmol/punch. However, divergent efficacy results in the first generation randomized clinical trials of F/TDF PrEP among African women led to several hypotheses to question whether the pharmacology and adherence requirement for oral F/TDF PrEP may be different in cisgender women compared to what is already established for men.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Capturing the dynamic changes in patients' internal states as they approach death due to fatal diseases remains a major challenge in understanding individual pathologies and improving end-of-life care. However, existing methods primarily focus on specific test values or organ dysfunction markers, failing to provide a comprehensive view of the evolving internal state preceding death. To address this, we analyzed electronic health record (EHR) data from a single institution, including 8,976 cancer patients and 77 laboratory parameters, by constructing continuous mortality prediction models based on gradient-boosting decision trees and leveraging them for temporal analyses.
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