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Dissolution of atmospheric plasma sprayed (APS) hydroxyapatite (HAp) coatings on Ti-6Al-4 V medical implants have always been a challenge to overcome in the field of biomedical industry. In the present work, an attempt has been made to develop a HAp coating using a novel thermal spray process called axial suspension plasma spraying (SPS), which leads to thin adherent coatings. Two HAp coatings fabricated by APS (P1 and P2) and four SPS HAp coatings (S1, S2, S3 and S4) produced with varying spraying parameters were characterized in terms of (1) microstructure, porosity, hardness, adhesion strength, contact angle and phase purity; (2) corrosion resistance in 10% Fetal bovine serum (FBS); (3) in-vitro cell adherence and cell viability using human umbilical cord blood-derived mesenchymal stem cells (hMSCs). Amongst different APS and SPS coatings, P1 and S3 exhibited superior properties. S3 coating developed using SPS exhibited 1.3 times higher adhesion strength when compared to APS coating (P1) and 9.5 times higher corrosion resistance than P1. In addition, both S3 and P1 exhibited comparatively higher biocompatibility as evidenced by the presence of more than 92% viable hMSCs.
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http://dx.doi.org/10.1016/j.colsurfb.2018.10.071 | DOI Listing |
J Orthop
November 2025
Instituto de Biotecnología, Universidad Nacional de Colombia, Bogotá, 111321, Colombia.
Background: Implant-associated infections remain a major clinical challenge in orthopedic surgery, often caused by microbial biofilms that resist conventional antibiotic treatments. Developing multifunctional coatings that combine bioactivity and antimicrobial properties is critical to improving the long-term performance of orthopedic implants.
Objective: To design and evaluate multilayered coatings that inhibit both bacterial and fungal colonization on orthopedic implant materials, while maintaining structural and chemical properties suitable for osseointegration.
Am J Sports Med
September 2025
Department of Orthopedics and Traumatology, Istanbul University Faculty of Medicine, Istanbul, Türkiye.
Background: Anterior cruciate ligament (ACL) injuries are prevalent among athletes and the general population, with ACL reconstruction (ACLR) being the standard treatment. However, effective tendon-bone healing (TBH) remains a challenge. Hydroxyapatite (HAp), widely used in orthopaedics and dentistry, has yet to be fully explored for its potential to enhance TBH.
View Article and Find Full Text PDFAnal Chem
August 2025
Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Cryogenic transmission electron microscopy (cryo-TEM) enables the visualization of liquid-phase materials, including nanoparticles and soft/biomaterials, under cryogenic conditions while minimizing radiation damage. Cryo-TEM imaging provides insights into particle size, shape, and dispersion. Beyond such conventional structural information, acquiring elemental composition data allows for a more detailed analysis and evaluation.
View Article and Find Full Text PDFJ Mater Chem B
August 2025
Chemistry and Biochemistry Department, Long Island University, Brooklyn, New York 11201, USA.
Hydroxyapatite (Hap) has limited intrinsic antimicrobial properties, which can be significantly enhanced by incorporating silver nanoparticles (AgNPs). The antibacterial properties of silver, particularly in the form of silver ions (Ag) and silver nanoparticles (AgNPs), are well-documented and extensively utilized in both biomedical and industrial applications. However, high concentrations of Ag or poorly dispersed silver nanoparticles can exert cytotoxic effects on mammalian cells, making it essential to optimize silver content and distribution to achieve an effective balance between antimicrobial efficacy and biocompatibility.
View Article and Find Full Text PDFEnviron Sci Technol
July 2025
State Key Laboratory of Efficient Utilization of Arable Land in China (Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences), Beijing 100081, China.
The incorporation of iron (Fe) into calcium carbonate coprecipitates (CCCs) to form Fe-incorporated CCC (CCCFe) widely occurred in CCC-enriched soils and sediments. However, the molecular mechanism of phosphate (P) immobilization on CCCFe remains largely unknown. In this study, batch experiments were conducted to investigate the immobilization mechanisms of P on CCCFe with low and high Fe loadings (CCCFe vs CCCFe) using P K-edge X-ray absorption near-edge structure (XANES) spectroscopy with surface-sensitive total electron yield (P-XANES) and bulk-sensitive fluorescence yield (P-XANES) modes.
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