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http://dx.doi.org/10.3389/fgene.2018.00563 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFJ Addict Nurs
September 2025
Cecilie W. Toudahl, MSc, The College of Nursing, University of South Carolina, Columbia, South Carolina.a.
Substance misuse among college students continues to rise, with polysubstance use becoming increasingly common. Alcohol remains the most prevalent substance, with heavy episodic and high-quantity drinking linked to serious consequences, including injuries, assaults, and deaths. Concurrent use of alcohol and cannabis, as well as other illicit drugs, further compounds risks to health, safety, and academic functioning.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
September 2025
University Clinic for Orthopedic Surgery and Traumatology, Kantonsspital Baselland, Bruderholz, Switzerland.
Kinematic alignment is increasingly adopted in total knee arthroplasty (TKA) as a patient-specific strategy to restore native joint anatomy. However, its reliance on static radiographic measurements may not adequately reflect real-world functional biomechanics. This editorial underscores the importance of complementing static assessment with kinetic principles.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
September 2025
UCHealth, Loveland, Colorado, USA.
Traumatic injury is the leading cause of death for individuals aged 1-45 in the USA. Variations in patient management based on geographic locations, community resources, and provider characteristics contribute to disparities in patient outcomes. It is estimated that 20,000 Americans lives could be saved yearly if all trauma centers performed as well as the highest-performing center, which is achievable, in part, through the reduction of inappropriate practice variation.
View Article and Find Full Text PDFAnn Gastroenterol Surg
September 2025
Aim: The reasons behind the high prevalence of poorly differentiated gastric cancer in young females remain unclear. Therefore, this study aimed to conduct a comprehensive genetic analysis to investigate the factors responsible for the high prevalence of poorly differentiated gastric cancer in young females.
Methods: We analyzed 299 patients who underwent gastric cancer surgery at the Gunma University Hospital between April 2015 and December 2020.