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The application and theoretical analysis of fault tolerant learning are very important for neural networks. Our objective here is to realize fault tolerant sparse multilayer perceptron (MLP) networks. The stochastic gradient descent method has been employed to perform online learning for MLPs. For weight noise injection-based network models, it is a common strategy to add a weight decay regularizer while constructing the objective function for learning. However, this l -norm penalty does not generate sparse optimal solutions. In this paper, a group lasso penalty term is used as a regularizer, where a group is defined by the set of weights connected to a node from nodes in the preceding layer. Group lasso penalty enables us to prune redundant hidden nodes. Due to its nondifferentiability at the origin, a smooth approximation of the group lasso penalty is developed. Then, a rigorous proof for the asymptotic convergence of the learning algorithm is provided. Finally, some simulations have been performed to verify the sparseness of the network and the theoretical results.
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http://dx.doi.org/10.1109/TCYB.2018.2864142 | DOI Listing |
J Hepatocell Carcinoma
September 2025
Department of Liver Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Objective: Anoikis is an anchorage-dependent programmed cell death implicated in multiple pathological processes of cancers; however, the prognostic value of anoikis-related genes (ANRGs) in hepatocellular carcinoma (HCC) remains unclear. Our study aims to develop an ANRGs-based prediction model to improve prognostic assessment in HCC patients.
Methods: The RNA-seq profile was performed to estimate the expression of ANRGs in HCC patients.
J Pain Res
September 2025
Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China.
Purpose: Postoperative hyperalgesia (POH) is a common clinical phenomenon that will increase the experience of patients' pain. Previous studies have confirmed that surgical site, opioid analgesics, gender, and age were risk factors of POH. Limited research has been investigated to prove the association between obstructive sleep apnea (OSA) and POH.
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August 2025
Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Acute myocardial infarction (AMI) patients with prior malignancy have been largely understudied, despite potentially facing higher risks of adverse outcomes. This case-control study aimed to identify independent risk factors for in-hospital mechanical complications among AMI patients with prior malignancies.
Methods: This study enrolled AMI patients with prior malignancy who were hospitalized for treatment.
Alpha Psychiatry
August 2025
Information Sciences and Technology, George Mason University, Fairfax, VA 22030, USA.
Background: Herein, we report on the initial development, progress, and future plans for an autonomous artificial intelligence (AI) system designed to manage major depressive disorder (MDD). The system is a web-based, patient-facing conversational AI that collects medical history, provides presumed diagnosis, recommends treatment, and coordinates care for patients with MDD.
Methods: The system includes seven components, five of which are complete and two are in development.
Diagn Pathol
September 2025
Department of Gastrointestinal Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Background: Gastric cancer is one of the most common cancers worldwide, with its prognosis influenced by factors such as tumor clinical stage, histological type, and the patient's overall health. Recent studies highlight the critical role of lymphatic endothelial cells (LECs) in the tumor microenvironment. Perturbations in LEC function in gastric cancer, marked by aberrant activation or damage, disrupt lymphatic fluid dynamics and impede immune cell infiltration, thereby modulating tumor progression and patient prognosis.
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