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Objective: to study the expression of the tissue factor (TF) and its correlation with prognosis and survival in patients with gastric carcinoma.
Methods: we measured the immunohistochemical expression of TF in 50 specimens of gastric adenocarcinomas from patients submitted to curative surgery. We then compared the intensity of its expression with clinical and pathological data, TNM staging, prognostic factors and survival.
Results: all tumors displayed TF expression; the intensity of TF expression was not associated with TNM stage, clinical or pathological variables or general survival.
Conclusion: TF has a high expression in gastric carcinoma, but that it is not useful as a prognostic marker.
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http://dx.doi.org/10.1590/0100-6991e-20182030 | DOI Listing |
PLoS One
September 2025
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
In adult mammals and other highly developed animals, incomplete wound healing, scar formation, and fibrosis occur. No treatment for complete tissue regeneration is currently available. However, in mice, at up to 13 days of gestation, early embryonic wounds regenerate without visible scarring.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
September 2025
Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.
The A20 binding inhibitor of nuclear factor-kappa B (NF-κB)-1 (ABIN-1) serves as a ubiquitin sensor and autophagy receptor, crucial for modulating inflammation and cell death. Our previous in vitro investigation identified the LC3-interacting region (LIR) motifs 1 and 2 of ABIN-1 as key mitophagy regulators. This study aimed to explore the in vivo biological significance of ABIN1-LIR domains using a novel CRISPR-engineered ABIN1-ΔLIR1/2 mouse model, which lacks both LIR motifs.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Department of Periodontology, Faculty of Dentistry, University of Çukurova;
Platelet-Rich Fibrin (PRF) is an autologous matrix rich in platelets, leukocytes, and growth factors that support tissue regeneration. Enhancing its structural and biological properties through biomaterial supplementation may improve clinical outcomes. This study evaluated the effects of adding hyaluronic acid (HA) and collagen to PRF on growth factor release and mechanical strength.
View Article and Find Full Text PDFmBio
September 2025
Department of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, Illinois, USA.
infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. Clumping factor A (ClfA) displayed on the bacterial surface plays a key role in promoting replication during invasive disease. Decades of research have pointed to a wide array of ligands engaged by ClfA.
View Article and Find Full Text PDFClin Spine Surg
September 2025
Department of Neurosurgery, Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane.
Study Design: Retrospective cohort study.
Objective: To characterise patients admitted to a UK tertiary centre with OPLL over a 10-year period.
Summary Of Background Data: OPLL is a progressive degenerative condition that can lead to myelopathy.