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Investigate the construct validity of prognostic factors purported to predict clinical success with stabilization exercise for low back pain by exploring their associations with lumbar multifidus composition. Patients with low back pain were recruited from a hospital imaging department. The presence of fivepredictors (age <40 years, positive prone instability test, aberrant trunk flexion movements, straight leg raise range of motion >91°, spinal hypermobility) were identified by standardized physical examination. Predictors were grouped by total positive findings and status on a clinical prediction rule. The proportion of lower lumbar multifidus intramuscular adipose tissue was measured with 3.0 T magnetic resonance imaging. Univariate and multivariate associations were examined with linear regression and reported with standardized beta coefficients (β) and 95% confidence intervals. Data from 62 patients (11 female) with mean (SD) age of 45.2 (11.8) years were included. Total number of predictors (β[95% CI] = -0.37[-0.61,-0.12]; = 0.12), positive prediction rule status (β[95% CI] = -0.57[-0.79,-0.35]; = 0.30), and age <40 years were associated with lower intramuscular adipose tissue (β[95% CI] = -0.55[-0.77,-0.33]; = 0.27). No other individual factors were associated with lumbar multifidus intramuscular adipose tissue. These findings support the construct validity of the grouped prognostic criteria. Future research should examine the clinical utility of these criteria. Implications for RehabilitationLow back pain is the single largest cause of disability worldwide and exercise therapy is recommended by international low back pain treatment guidelines.Lower levels of lumbar multifidus intramuscular adipose tissue were associated with predictors of clinical success with stabilization exercise.Higher proportions of lumbar multifidus intramuscular adipose tissue may help identify patients who require longer duration exercise training, or those who are unlikely to respond to stabilization exercise.
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http://dx.doi.org/10.1080/09638288.2018.1506510 | DOI Listing |
PLoS One
September 2025
Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong.
Objective: Backward walking may promote the preferential recruitment of lumbar extensors to optimize flexed spinal posture adopted LBP flexion subgroup. This cross-sectional study investigated the backward-walking exercise on a) real-time muscle activation, and b) its immediate effect on back pain intensity, movement control and lumbopelvic muscle activation in individuals with chronic non-specific LBP characterized with lumbar flexion syndrome.
Method: Thirty adults with chronic non-specific LBP with clinical manifestation of flexion syndrome received assessments of their movement control at static standing and during the five-minute forward walking test, conducted before and after a 15-minute treadmill walking training in forward or backward direction (as the immediate effect), while real-time adaptation of the lumbopelvic muscles during walking training was also evaluated.
Eur Spine J
September 2025
Marmara University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation , Istanbul, Turkey.
Purpose: The aim of this study is to investigate the role of the cross-sectional area (CSA) of the lumbar paraspinal muscles in the development of degenerative and isthmic spondylolisthesis and its effect on the percentage of slip (PoS).
Methods: This retrospective single-center study included 171 patients, 100 of whom were isthmic and 71 patients with degenerative lumbar spondylolisthesis. First, CSAs of bilateral psoas major (PM), erector spinae (ES), and multifidus (MF) muscles were measured using MRI, and then the ratio of muscle areas to L5 vertebral body (VB) area was calculated.
Comput Methods Biomech Biomed Engin
September 2025
School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
This study compared biomechanical impacts of conventional open surgery (COS) and minimally invasive surgery (MIS) for spondylolisthesis using a musculoskeletal model with in-vivo data from 31 patients undergoing L4-L5 fusion. Pre- and post-operative conditions with simulated muscle injury were analyzed, focusing on kinematics, muscle forces, and adjacent segment loading. Both methods altered lumbosacral parameters, but COS caused greater lumbar-pelvic rhythm reduction (60% vs.
View Article and Find Full Text PDFEur J Pain
October 2025
Department of Neurophysiology, Mannheim Centre for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Background: Chronic primary low back pain (cpLBP) is prevalent worldwide. Adverse childhood experiences (ACEs) increase the risk of cpLBP. Here, we explored ACEs as a predisposing factor for adult cpLBP using a rodent model.
View Article and Find Full Text PDFEur Spine J
August 2025
Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Purpose: This study aimed to investigate the potential association between paraspinal muscle (PSM) degeneration, osteoporosis, and vertebral rotatory subluxation (VRS) in patients with degenerative lumbar scoliosis (DLS).
Methods: This retrospective study analyzed standing anteroposterior radiographs to assess the coronal (Cobb angle, coronal balance distance, and lateral translation) and sagittal parameters (thoracic kyphosis, lumbar lordosis, and sagittal vertical axis). Patients were categorized into rotatory subluxation (RS, lateral translation ≥ 5 mm) and non-RS groups, with the RS group further subdivided into single- and double-level subgroups based on the frequency of RS occurrence.