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Soils are vital for supporting food security and other ecosystem services. Climate change can affect soil functions both directly and indirectly. Direct effects include temperature, precipitation, and moisture regime changes. Indirect effects include those that are induced by adaptations such as irrigation, crop rotation changes, and tillage practices. Although extensive knowledge is available on the direct effects, an understanding of the indirect effects of agricultural adaptation options is less complete. A review of 20 agricultural adaptation case-studies across Europe was conducted to assess implications to soil threats and soil functions and the link to the Sustainable Development Goals (SDGs). The major findings are as follows: (a) adaptation options reflect local conditions; (b) reduced soil erosion threats and increased soil organic carbon are expected, although compaction may increase in some areas; (c) most adaptation options are anticipated to improve the soil functions of food and biomass production, soil organic carbon storage, and storing, filtering, transforming, and recycling capacities, whereas possible implications for soil biodiversity are largely unknown; and (d) the linkage between soil functions and the SDGs implies improvements to SDG 2 (achieving food security and promoting sustainable agriculture) and SDG 13 (taking action on climate change), whereas the relationship to SDG 15 (using terrestrial ecosystems sustainably) is largely unknown. The conclusion is drawn that agricultural adaptation options, even when focused on increasing yields, have the potential to outweigh the negative direct effects of climate change on soil degradation in many European regions.
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http://dx.doi.org/10.1002/ldr.3006 | DOI Listing |
Future Oncol
September 2025
Division of Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is characterized by the fusion gene which produces a constitutively active tyrosine kinase which drives disease pathogenesis and is associated with resistance to conventional chemotherapy. Intensive cytotoxic chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT), the historical treatment paradigm for Ph+ ALL, was associated with poor outcomes. The introduction of inhibitors of ABL1 revolutionized the treatment of Ph+ ALL.
View Article and Find Full Text PDFHealth Soc Care Deliv Res
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: Remote services (in which the patient and staff member are not physically colocated) and digital services (in which a patient encounter is digitally mediated in some way) were introduced extensively when the COVID-19 pandemic began in 2020. We undertook a longitudinal qualitative study of the introduction, embedding, evolution and abandonment of remote and digital innovations in United Kingdom general practice. This synoptic paper summarises study design, methods, key findings, outputs and impacts to date.
View Article and Find Full Text PDFJ Pain Symptom Manage
September 2025
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland and Department of Palliative Care Centre and Home Hospital Services, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Finland.
Context: High-flow nasal therapy (HFNT) may relieve severe dyspnea, but its role compared to other treatment options in palliative care remains unclear.
Objectives: Assess the effect and feasibility of HFNT with air compared to fan therapy in relieving dyspnea among non-hypoxemic patients with incurable cancer.
Methods: This prospective, randomized, controlled, crossover trial compared airflow delivered by HFNT and fan.
Biomater Adv
August 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India; Centre of Medical Device, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India. Electronic address:
Spinal cord injury presents a significant clinical challenge. There are limited treatment options, and the results of regeneration are often disappointing. Secondary injury processes, including oxidative stress and chronic inflammation, worsen nerve damage and slow recovery.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America.
Real-world decision-making often involves navigating large action spaces with state-dependent action values, taxing the limited cognitive resources at our disposal. While previous studies have explored cognitive constraints on generating action consideration sets or refining state-action mappings (policy complexity), their interplay remains underexplored. In this work, we present a resource-rational framework for policy compression that integrates both constraints, offering a unified perspective on decision-making under cognitive limitations.
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