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In this article, we report a case of tuberculosis spondylodiscitis in a 2-year-old child. Imaging of her spine showed a paraspinal abscess. The diagnosis of spinal tuberculosis remains difficult, and we discuss its salient features and current management within the pediatric population.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195007 | PMC |
http://dx.doi.org/10.1177/2333794X18805614 | DOI Listing |
Contemp Clin Trials
September 2025
Weill Cornell Medicine Center for Global Health, New York, NY, USA.
Introduction: Preclinical and clinical study data show that combining bedaquiline (B or BDQ), moxifloxacin (M), and pyrazinamide (Z), known as BMZ, has potent antimicrobial activity that might shorten treatment duration for drug-susceptible pulmonary tuberculosis.
Methods/design: We describe the design of Tuberculosis Trials Consortium (TBTC) Study 38/CRUSH-TB (NCT05766267), an open-label multicenter international randomized controlled phase 2C trial that compares two four-month regimens, BMZ plus rifabutin (Rb) (2BMZRb/2BMRb) or BMZ plus delamanid (D or DLM) (2BMZD/2BMD), with standard 6-months isoniazid, rifampin, pyrazinamide, and ethambutol (HRZE). All drugs are administered seven days per week, under direct observation, at least five days per week.
BMJ Case Rep
September 2025
Cardiology, Dr D Y Patil Medical College Hospital and Research Centre, Pune, Maharashtra, India
Constrictive pericarditis is a condition in which inflammation of the pericardium results in the loss of pericardial elasticity, leading to restricted ventricular filling. This case reports a male in his 50s who presented with symptoms of bilateral pedal oedema and dyspnoea. Examination revealed a raised jugular venous pulse, abdominal dullness and crepitations in both lungs.
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September 2025
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Background: Tuberculosis (TB), a disease caused by bacteria of the (MTC), is one of the oldest diseases in human history, and despite several global efforts to reduce case numbers, it remains one of the main causes of death worldwide due infectious agents. This study aimed to analyze the epidemiological trends of tuberculosis in Minas Gerais, Brazil, from 2013 to 2023, with emphasis on the impact of the COVID-19 pandemic on case notification.
Methods: Based on epidemiological data obtained from the DATASUS platform, spanning the period from 2013 to 2023, the number of cases, the distribution of confirmed cases by sex, race, education, age group, HIV co-infection and presence of comorbidities such as diabetes, and risk factors like smoking and alcoholism were evaluated.
IJU Case Rep
September 2025
Department of Urology Toyama University Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama Japan.
Introduction: The association between the risk of latent tuberculosis infection (LTBI) reactivation and immune checkpoint inhibitor (ICI) administration has been reported.
Case Presentation: A man in his seventies underwent robot-assisted laparoscopic radical cystectomy with ileal conduit diversion for muscle-invasive bladder cancer. Three years postoperatively, CT revealed metastases to the para-aortic lymph nodes and rectum.
Cureus
August 2025
Neurology, Government Medical College, Amritsar, Amritsar, IND.
Tubercular (TB) meningitis is one of the manifestations of central nervous system tuberculosis, a form of extrapulmonary tuberculosis. Despite the high incidence of TB meningitis in developing countries, there are hardly any reports of associated ventriculitis, making it one of the rare complications. Ventriculitis complicating TB meningitis is devastating not only to the immunocompromised but also to the immunocompetent population.
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