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Purpose: Latest research on cochlear implantations focuses on hearing preservation during insertion of the implant's electrode array by reducing insertion trauma. One parameter which may influence trauma is insertion speed. The objective of this study was to extend the range of examined insertion speeds to include ultra-low velocities, being lower than manually feasible, and investigate whether these reduce insertion forces.
Methods: 24 custom-made cochlear implant test samples were fabricated and inserted into an artificial scala tympani model using 12 different insertion speeds while measuring the resulting insertion forces. Three commercially available slim straight electrode carriers were inserted using the same setup to analyze whether the results are comparable.
Results: Insertions of the test samples using high insertion speeds (2.0/2.8 mm/s) showed significantly higher insertion forces than insertions done with low insertion speeds (0.2 mm/s) or ultra-low insertion speeds (< 0.1 mm/s). The insertions with commercial slim straight electrode arrays showed significantly reduced insertion forces when using a low insertion speed as well.
Conclusions: Slow insertions showed significantly reduced insertion forces. Insertion speeds which are lower than manually feasible showed even lower insertion forces.
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http://dx.doi.org/10.1007/s00405-018-5159-1 | DOI Listing |
Med Eng Phys
October 2025
Department of Engineering Science, University of Oxford, United Kingdom. Electronic address:
Traditionally, clinical devices are designed, tested and improved through lengthy and expensive laboratory experiments and clinical trials [1]. More recently, computational methods have allowed for rapid testing, speeding up the design process and enabling far more complete searches of design space. While computational models cannot fully capture the complexities of biological systems, they provide valuable insights into crucial underlying mechanisms, such as the effects of fluid-structure interactions (FSIs).
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August 2025
Kenya Agricultural Livestock Research Organization, Nairobi, Kenya.
Transposon-based genetic transformation enables stable transgene integration in avian genomes and is increasingly used in the development of transgenic chickens for enhanced disease resistance, productivity, and biopharmaceutical applications. Conventional transformation techniques in avian biotechnology, including viral vectors and primordial germ cell (PGC) manipulation, are limited by biosafety risks, low efficiency, and technical complexity. This protocol outlines a two-step cloning approach for generating transposon-compatible gene constructs suitable for chicken embryo microinjection.
View Article and Find Full Text PDFBMC Bioinformatics
August 2025
School of Computer Science and Engineering, Sun Yat-sen University, Waihuan Dong Road, Guangzhou, 510006, China.
In the genome analysis workflow, Genome Analysis Toolkit (GATK) HaplotypeCaller is a widely used variant calling tool designed to accurately identify single nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) in samples. However, when processing large-scale datasets, HaplotypeCaller often faces the challenge of excessively long runtime. Parallelizing GATK HaplotypeCaller with data segmentation is an effective solution, but existing methods struggle to accurately estimate the computational complexity of each data block, leading to severe computational skew.
View Article and Find Full Text PDFJBJS Essent Surg Tech
August 2025
Department of Orthopaedics, Faculty of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Over the last 30 years, total ankle arthroplasty (TAA) has become a viable surgical option for end-stage ankle arthritis. The aim of TAA is to relieve pain and preserve ankle joint range of motion, which, by definition, shields adjacent joints. Alignment is essential for the longevity and survival of TAA, since malalignment of TAA components can cause abnormal loading patterns with subsequent polyethylene wear and early implant failure.
View Article and Find Full Text PDFSensors (Basel)
July 2025
Humanoid and Cognitive Robotics Lab, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.
In this paper, we propose an active touch sensing algorithm designed for robust hole localization in 3D objects, specifically aimed at assembly tasks such as peg-in-hole operations. Unlike general object detection algorithms, our solution is tailored for precise localization of features like hole openings using sparse tactile feedback. The method builds on a prior 3D map of the object and employs a series of iterative search algorithms to refine localization by aligning tactile sensing data with the object's shape.
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