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http://dx.doi.org/10.4103/0366-6999.241801 | DOI Listing |
Eur Arch Psychiatry Clin Neurosci
September 2025
Tianjin Anding Hospital, Institute of Mental Health, Psychiatric Medical Center of Tianjin University, Mental Health Center of Tianjin Medical University, 13 Liulin Road, Tianjin, 300222, China.
Background: Elevated homocysteine levels, known as hyperhomocysteinemia (HHcy), have been implicated in the pathophysiology of schizophrenia. Most prior studies focused on first-episode or acute-phase schizophrenia patients, leaving the prevalence, determinants, and clinical correlates of HHcy in chronic schizophrenia understudied. This study aims to investigate the prevalence and determinants of HHcy in patients with chronic schizophrenia, as well as its clinical correlates.
View Article and Find Full Text PDFBiomolecules
August 2025
Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought to light unexpected complications beyond respiratory illness, including effects on kidney function and a potential link to kidney stone disease (KSD). This review proposes a novel framework connecting COVID-19-induced epigenetic reprogramming to disruptions in mitochondrial sulfur metabolism and the pathogenesis of kidney stones. We examine how SARS-CoV-2 interferes with host methylation processes, leading to elevated homocysteine (Hcy) levels and impairment of the trans-sulfuration pathway mechanisms particularly relevant in metabolic disorders such as homocystinuria.
View Article and Find Full Text PDFBMC Ophthalmol
August 2025
Department of Ophthalmology, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan (deemed to be) University, 8-Kalinga Nagar, Bhubaneswar, 751003, India.
Background: To study the clinical profile of patients diagnosed with retinal vein occlusion (RVO) and its correlation with serum Homocysteine (Hcy) levels.
Methods: This hospital-based cross-sectional study included all patients aged more than 18 years presenting to the Department of Ophthalmology from August 2024 to January 2025. A comprehensive ocular examination was done in all cases.
Case Rep Neurol Med
August 2025
Department of Neurology, University of Texas Medical Branch and Hospitals (UTMB), Galveston 77550, Texas, USA.
Vitamin B12 deficiency can cause subacute combined degeneration (SACD) by disrupting myelin synthesis, leading to spinal cord degeneration. We present a unique case of SACD featuring symmetrical pseudoathetosis characterized by involuntary, slow, and writhing movements resulting from proprioceptive sensory impairment, which disrupts the brain's ability to accurately perceive limb position and movement and pulmonary embolism due to elevated homocysteine levels. A 34-year-old male presented with chest pain, generalized weakness, and numbness in his hands and feet.
View Article and Find Full Text PDFClin Exp Pediatr
July 2025
Azerbaijan Medical University, Department of Medical and Biological Physics, Baku, Azerbaijan.
Background: Homocysteine metabolism is crucial to maintaining vascular and metabolic homeostasis, yet its dysregulation in pediatric β-thalassemia major (β-TM) remains poorly understood.
Purpose: This study investigated the prevalence and determinants of hyperhomocysteinemia in pediatric β-TM with a focus on vitamin B9 (folate), B12, and B6 deficiencies, oxidative stress marker levels, and the impact of splenectomy.
Methods: A cross-sectional study was conducted of 92 pediatric β-TM patients.