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Article Abstract
This study evaluated the effects of [d-Leu¹]Microcystin-LR variant by the exposure of tadpole to unialgal culture NPLJ-4 strain. The Tadpole was placed in aquariums and exposed to culture or disrupted cells. For 16 days, 5 individuals were removed every 2 days, and tissue samples of liver, skeletal muscle, and intestinal tract were collected for histopathology and bioaccumulation analyses. After exposure, those surviving tadpoles were placed in clean water for 15 days to evaluate their recovery. A control without algae and toxins was maintained in the same conditions and exhibited normal histology and no tissue damage. In exposed tadpoles, samples were characterized by serious damages that similarly affected the different organs, such as loss of adhesion between cells, nucleus fragmentation, necrosis, and hemorrhage. Samples showed signs of recovery but severe damages were still observed. Neither HPLC-PDA nor mass spectrometry analysis showed any evidence of free Microcystins bioaccumulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116141 | PMC |
| http://dx.doi.org/10.3390/toxins10080318 | DOI Listing |
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