The fast block to polyspermy: New insight into a century-old problem.

J Gen Physiol

Department of Cell Biology, University of Connecticut Health Center, Farmington, CT

Published: September 2018


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Jaffe underscores new research that identifies key roles for IP and TMEM16a in the fast block to polyspermy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122926PMC
http://dx.doi.org/10.1085/jgp.201812145DOI Listing

Publication Analysis

Top Keywords

fast block
8
block polyspermy
8
polyspermy insight
4
insight century-old
4
century-old problem
4
problem jaffe
4
jaffe underscores
4
underscores identifies
4
identifies key
4
key roles
4

Similar Publications

Introduction: Accurate identification of cherry maturity and precise detection of harvestable cherry contours are essential for the development of cherry-picking robots. However, occlusion, lighting variation, and blurriness in natural orchard environments present significant challenges for real-time semantic segmentation.

Methods: To address these issues, we propose a machine vision approach based on the PIDNet real-time semantic segmentation framework.

View Article and Find Full Text PDF

Objective: To develop a deep learning method for fast and accurate prediction of Specific Absorption Rate (SAR) distributions in the human head to support real-time hyperthermia treatment planning (HTP) of brain cancer patients.

Approach: We propose an encoder-decoder neural network with cross-attention blocks to predict SAR maps from brain electrical properties, tumor 3D isocenter coordinates and microwave antenna phase settings. A dataset of 201 simulations was generated using finite-element modeling by varying tissue properties, tumor positions, and antenna phases within a human head model equipped with a three-ring phased-array applicator.

View Article and Find Full Text PDF

Photodegradable nanoparticles with sphere, worm, and vesicle morphologies were synthesized following polymerization induced self-assembly (PISA), incorporating a photoresponsive phenyl vinyl ketone (PVK) block and a nonphoto responsive 2-hydroxypropyl methacrylamide (HPMA) block. The photodegradation of nanoparticles under UV revealed that the initial shapes of sphere and vesicle particles are retained even until 7 h and after 24 h of photo-induced degradation, respectively, despite a significant reduction in molecular weight (M). This could be due to the assembly of degraded PVK fragments in the hydrophobic region, maintaining the relative hydrophilic to hydrophobic ratio.

View Article and Find Full Text PDF

Background: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol in drug-susceptible tuberculosis.

Methods: Clo-Fast was a phase 2c open-label trial recruiting participants at six sites in five countries.

View Article and Find Full Text PDF

Theoretical and experimental study on a fast proton transport pathway in CeO-coated SrTiO through surface vacancy engineering for low-temperature ceramic fuel cells.

J Colloid Interface Sci

August 2025

College of Mechatronics and Control Engineering & State Key Lab of Radio Frequency Heterogenous Integration, Shenzhen University, Shenzhen 518060, China. Electronic address:

Overcoming the high-temperature limitations of ceramic fuel cells (CFCs) requires the development of electrolytes capable of efficient proton transport at reduced operating temperatures. In this work, we introduced a surface-engineered SrTiO electrolyte coated with 10 mol%-CeO, forming a core-shell heterostructure that promoted the formation of oxygen vacancies localized at the interface. These vacancies significantly reduced the energy barrier for proton migration, enabling enhanced ionic conductivity at low operating temperatures.

View Article and Find Full Text PDF