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The insecticidal activity of parasiticide residues in dung of cattle treated with a sustained release eprinomectin formulation was examined, and an improved eprinomectin dung residue extraction method is presented. Emergent insect abundance and richness were significantly reduced in all post-treatment intervals (7, 14, 28, 56, 84, 112, and 140 d), relative to pre-treatment. Emergent insect diversity was reduced for between 84 and 112 d post-treatment. Collembola were not affected by residues. Chemical analyses subsequently documented residues of eprinomectin in dung of each collection period post-treatment at levels expected based on previously reported excretion profiles for this product. Cattle subcutaneously injected with this product excreted residues that reduced dung-breeding insect emergence for 5 mo post-treatment. The consequences of these long-term non-target effects to pasture ecosystems are not known.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078490 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201074 | PLOS |
J Drug Target
September 2025
Department of Pharmacology, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra, INDIA.
Natural phytoconstituents such as betanin and curcumin have attracted interest for their significant antioxidant and anti-inflammatory properties. Their therapeutic efficacy is notably constrained by inadequate bioavailability and reduced skin permeability. The current study developed an ethosome-based gel system for the delivery of betanin and curcumin, with the objective of improving transdermal penetration and providing sustained anti-inflammatory effects.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Infected wound treatment remains a critical challenge in clinical medicine. Although existing treatments, like local debridement, antimicrobial agents, and growth factor therapies, have demonstrated certain therapeutic effects, they primarily target only specific stages of wound healing. Moreover, the escalating issue of antibiotic resistance limits their efficacy.
View Article and Find Full Text PDFRegen Biomater
August 2025
College of Textiles & Clothing, Institute of Functional Textiles and Advanced Materials, Qingdao 266071, China.
Bacterial infection in the injured skin may threaten the wound repair and skin regeneration owing to aggravated inflammation. The multifunctional dressings with persistent antibacterial activity and improved anti-inflammatory capability are urgently required. Herein, a type of heterogeneous zinc/catechol-derived resin microspheres (Zn/CFRs) composed of zinc ions (Zn) and zinc oxide (ZnO) nanoparticles was developed to impart the methacrylamide chitosan (CSMA)-oxidized hyaluronic acid (OHA) hydrogel with a persistent Zn release behavior.
View Article and Find Full Text PDFRSC Adv
September 2025
School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 211816 China
Diabetic wounds present persistent challenges due to impaired healing, recurrent infection, oxidative stress, and dysregulated glucose metabolism. Bioinspired polymeric microneedle (MN) patches have emerged as multifunctional platforms capable of penetrating the stratum corneum to deliver therapeutics directly into the dermis, enabling glucose regulation, antimicrobial action, reactive oxygen species (ROS) modulation, and proangiogenic stimulation. Recent experimental evidence has demonstrated that the integration of glucose oxidase-loaded porous metal-organic frameworks, photothermal nanomaterials, and antioxidant hydrogels within dissolvable MNs achieves synergistic bactericidal effects, accelerates collagen deposition, and enhances neovascularization in diabetic wound models.
View Article and Find Full Text PDFPatterns (N Y)
July 2025
OPENGIS.ch GmbH, 7031 Laax, Switzerland.
The QGIS project is a prominent open-source geographic information system (GIS) that has evolved over two decades, contributing significantly to the geospatial community. This paper presents the development, governance, and operational challenges faced by QGIS, providing an in-depth analysis of its growth from a hobby project to a global platform. We examine the project's organizational structure, release management, and infrastructure, alongside the financial model that sustains its development.
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