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Article Abstract
Background: An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI).
Methods: Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI.
Results: We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens at the final visit. Regarding final clinical cure, there was no difference in favour of the gentamicin-sponges (26/45 vs. 31/43; p = 0.16). However, the gentamicin-sponge arm tended to a more rapid healing. In multivariate analysis adjusting for the case-mix, the variable "gentamicin-sponge" was not significantly associated with "cure and improvement". Gentamicin-sponges were very well tolerated, without any attributed adverse events.
Conclusions: The gentamicin-sponge was very well tolerated, but did not significantly influence overall cure.
Trial Registration: ClinicalTrials.gov ( NCT01951768 ). Date 2 April 2013.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090847 | PMC |
| http://dx.doi.org/10.1186/s12879-018-3253-z | DOI Listing |
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