Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.aau3978 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neutralizing monoclonal antibodies against dengue virus: a scoping review of preclinical and clinical development.
Virology
September 2025
Department of Medicine, Democritus University of Thrace, Alexandroupolis, Evros, Greece.
Background: Dengue virus (DENV) is a major global health challenge, causing over 7.6 million reported cases in 2024. Neutralizing monoclonal antibodies (NmAbs) have emerged as promising therapeutics to address the limitations of vaccines and lack of antivirals, but their development is complicated by viral diversity, "breathing" dynamics, and antibody-dependent enhancement (ADE).
View Article and Find Full Text PDFFeasibility of an antimicrobial stewardship program in four district hospitals in Vietnam.
J Infect Public Health
September 2025
Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Woolcock Institute of Medical Research, Macquarie Park, Sydney, Australia.
Background: Excessive and improper use of antimicrobials is a major driver of antimicrobial resistance. Antimicrobial stewardship (AMS) addresses this by promoting judicious use of antimicrobials. This study evaluated the feasibility and effectiveness of an AMS program in district hospitals in Vietnam.
View Article and Find Full Text PDFDescription of chromatographic performance in reversed-phase liquid chromatography based on a generalised model. Part I: Column characterisation.
J Chromatogr A
August 2025
Department of Analytical Chemistry, Faculty of Chemistry, Universitat de València, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Spain.
Liquid chromatography has advanced considerably since its introduction in the 1970s, with reversed-phase liquid chromatography (RPLC) becoming the dominant technique for separating non-volatile molecules. A key strategy for optimising separation conditions is the modelling of chromatographic retention from experimental data. Traditionally, this is achieved by fitting model parameters for each solute, resulting in individual solute models (ISMs).
View Article and Find Full Text PDFFacile synthesis of highly active PtSnCoNi hierarchical dendritic nanowires greatly boosting signal amplification for ultrasensitive immunoassay of biomarker HER-2.
Bioelectrochemistry
August 2025
Department of General Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-Sen University, Huizhou, Guangdong 516081, China. Electronic address:
Human epidermal growth factor receptor-2 (HER-2), a key biomarker in breast cancer, is critical for early diagnosis and prognosis evaluation. In this work, a label-free electrochemical immunosensor was developed for biomarker HER-2 detection based on PtSnCoNi hierarchical dendritic alloyed nanowires (PtSnCoNi HDNWs). These nanowires were synthesized via a co-reduction-triggered anisotropic growth strategy in oleylamine.
View Article and Find Full Text PDFSelf-phosphorylating DNAzyme DK1 enables programmable multi-analyte readout via PfAgo.
Biosens Bioelectron
September 2025
Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Precision Medicine Translational Research Programme (TRP), Yong Loo Lin School
DNAzymes possessing kinase-like activities have long held theoretical promise, yet their practical implementation has remained significantly limited. Notably, DNAzyme kinase 1 (DK1), discovered over two decades ago, exhibits a unique self-phosphorylation capability upon encountering specific substrates like ATP, but its broad-based and programmable applications have not yet been fully realized. In this study, we innovatively couple DK1's autophosphorylation mechanism with the PfAgo to establish a novel programmable cascade sensing platform named RASTEN (Robust pfAgo-based Strategy for POC Testing Non-nucleic Acid and Nucleic Acid).
View Article and Find Full Text PDF