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Longitudinal changes in compensatory and anticipatory postural adjustments around the knee were investigated from rupture of ACL until return to play after reconstruction. Twelve ACL-injured participants (ACL-P) were asked to respond to unpredictable and predictable perturbations before (T1), 2 (T2) and 6 months after (T3) reconstruction. Twelve healthy participants served as controls. Compensatory and anticipatory latencies of vastus lateralis (VL) and medialis (VM) were measured with respect to the arrival of perturbations. ACL-P showed delayed compensatory latencies compared to controls at T1 for VL (101±32 ms vs 63±7 ms) and VM (117±36 ms vs 75±17 ms) and at T2 for VL (94±20 ms vs 63±7 ms) and VM (94±27 ms vs 71±11 ms). ACL-P showed earlier anticipatory latencies than controls for VL at T1 (-69±44 ms vs -12±12 ms) and T2 (-46±17 ms vs -16±12 ms). At T3, ACL-P showed delayed compensatory latencies for VL (91±18 ms vs 56±21 ms) and VM (95±13 ms vs 66±4 ms), whilst anticipatory latencies were restored. Rehabilitation should address delayed compensatory responses.
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http://dx.doi.org/10.1055/a-0599-6401 | DOI Listing |
Clin Biomech (Bristol)
July 2025
Department of Rehabilitation Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan; Department of Orthopaedic Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan. Electronic address:
Background: This study aimed to measure anticipatory postural adjustment characteristics of patients with stroke hemiplegia during one-leg standing using a smartphone.
Methods: Participants included 20 patients with stroke hemiplegia and 10 healthy age-matched controls. A smartphone was attached to the pelvis (L5), and one-leg standing movement was measured.
Brain Topogr
May 2025
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road 2, Guangzhou, 510080, China.
Hemodynamic responses in the dorsolateral prefrontal cortex (DLPFC) during gait initiation could influence anticipatory postural adjustments (APAs). However, how DLPFC during motor preparation modulates APA integration remains unknown. Seventeen right-handed participants completed two sessions of the rapid arm raising task and simultaneously received the real and sham repetitive transcranial magnetic stimulation (rTMS) over the left DLPFC during the motor preparation period before arm raising.
View Article and Find Full Text PDFAlzheimers Dement
May 2025
Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Background: Maintenance of cerebral blood flow during orthostasis is impaired with aging and associated with cognitive decline, but the effect of the apolipoprotein ɛ4 allele (APOE4) is unknown.
Methods: Older adults (n = 108) (APOE4 carriers, n = 47; non-carriers, n = 61) diagnosed as having normal cognition (NC), mild cognitive impairment (MCI), or Alzheimer's disease (AD) underwent transcranial Doppler ultrasound assessment of middle cerebral artery blood velocity (MCAv) and beat-to-beat mean arterial blood pressure (MAP) during a sit-to-stand transition. Anticipatory and orthostasis-induced MCAv and MAP responses were compared between genotypes and diagnostic classifications.
Neuroscience
May 2025
Department of Rehabilitation - Donders Institute for Brain, Cognition & Behavior, Radboud University Medical Center, Nijmegen, NL, Nethelands; Sint Maartenskliniek Research, Nijmegen, NL, Nethelands.
Our ability to flexibly initiate rapid visually-guided stepping movements can be measured in the form of express visuomotor responses (EVRs), which are short-latency (∼100 ms), goal-directed bursts of lower-limb muscle activity. Interestingly, we previously demonstrated that recruitment of anticipatory postural adjustments (APAs) interacted with the subcortically-generated EVRs in the lower limb, suggesting context-dependent top-down modulation. We investigated the associated cortical dynamics prior to and during rapid step initiation towards a salient visual target in twenty-one young, healthy individuals while stepping under varying postural demands.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
May 2025
Current surface electromyography (sEMG) methods for locomotion mode prediction face limitations in anticipatory capability due to computation delays and constrained window lengths typically below 500 ms-a practice historically tied to stationarity requirements of handcrafted feature extraction. This study investigates whether end-to-end convolutional neural networks (CNNs) processing raw sEMG signals can overcome these constraints through extended window lengths (250 ms to 1500 ms). We systematically evaluate six window lengths paired with three prediction horizons (model forecasts 50 ms to 150 ms ahead) in a continuous locomotion task involving eight modes and 16 transitions.
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