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Background And Objective: The detection of optic nerve head (ONH) in retinal fundus images plays a key role in identifying Diabetic Retinopathy (DR) as well as other abnormal conditions in eye examinations. This paper presents a method and its associated software towards the development of an Android smartphone app based on a previously developed ONH detection algorithm. The development of this app and the use of the d-Eye lens which can be snapped onto a smartphone provide a mobile and cost-effective computer-aided diagnosis (CAD) system in ophthalmology. In particular, this CAD system would allow eye examination to be conducted in remote locations with limited access to clinical facilities.
Methods: A pre-processing step is first carried out to enable the ONH detection on the smartphone platform. Then, the optimization steps taken to run the algorithm in a computationally and memory efficient manner on the smartphone platform is discussed.
Results: The smartphone code of the ONH detection algorithm was applied to the STARE and DRIVE databases resulting in about 96% and 100% detection rates, respectively, with an average execution time of about 2 s and 1.3 s. In addition, two other databases captured by the d-Eye and iExaminer snap-on lenses for smartphones were considered resulting in about 93% and 91% detection rates, respectively, with an average execution time of about 2.7 s and 2.2 s, respectively.
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http://dx.doi.org/10.1016/j.cmpb.2018.05.004 | DOI Listing |
Front Mol Biosci
August 2025
Department of Ophthalmology, Affiliated Hospital of Yunnan University, Yunnan, China.
Purpose: To investigate the role of the lamina cribrosa (LC) astrocytes in the autoregulatory capacity of optic nerve head (ONH) vessels and to explore the underlying molecular mechanisms.
Methods: The Oxygen-glucose deprivation/reperfusion model (OGD/R) was constructed to examine the changes in cell morphology and protein expression in LC astrocytes. LC astrocytes were co-cultured with vascular smooth muscle cells (VSMCs) to detect the role of LC astrocytes in the autoregulatory function of vessels.
J Clin Med
August 2025
General University Hospital Morales Meseguer, 30008 Murcia, Spain.
Attention deficit hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder. As the retina is an extension of the central nervous system, retinal imaging may provide insights into the ADHD pathophysiology. The objective of this work was to evaluate structural retinal alterations using optical coherence tomography (OCT) in ADHD patients compared to neurotypical controls.
View Article and Find Full Text PDFInt J Ophthalmol
September 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Aim: To detect and segregate causative mutations in congenital families with optic nerve hypoplasia (ONH).
Methods: Two unrelated consanguineous Pakistani families with severe ONH, showing features of micropthalmia, nystagmus, corneal opacity, and keratopathy were included. Genetic analysis was carried out by Target Panel Sequencing, and the nucleotide variant was confirmed by Sanger sequencing.
Front Physiol
August 2025
Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Piezo channels are currently known to be the most sensitive molecular mechanoreceptors. Piezo can respond to membrane tension, sag, shear force, tensile and other mechanical stimuli, produces fast inactivation, small conductance, and low threshold current. In eukaryotic cells, Piezo has two family members: Piezo1 and Piezo2.
View Article and Find Full Text PDFInt Med Case Rep J
August 2025
Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, 09124, Italy.
Purpose: To report a case of non-arteritic ischemic optic neuropathy (NAION) in an otherwise healthy patient treated with Glucagon-Like Peptide-1 (GLP-1) receptor agonists (RAs) liraglutide and semaglutide.
Observations: A 47-year-old Caucasian female with a Body Mass Index (BMI) of 27.92, and no known history of diabetes, hypertension, or ischemic heart disease, developed a progressive decline in visual acuity in the right eye one month after initiating liraglutide therapy for weight loss.