Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The critical attribute was analyzed in clavulanate potassium tablet of amoxicillin according to the principle QbD. By investigation of the drug impurity profile, the cycle-closed dimer and penicilloic acid of amoxicillin were considered to be the critical impurities, and the sources and the degradation pathways of these two impurities were discussed. The research confirmed that crystal form was the critical attribute of drug substance. The drying process in the tablet granulation was regarded as the critical process parameter. The tablet formulation was also another factor in the impurity generation. This study provides a new idea for the evaluation of drug quality.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prevalence, characterization, and transmissible factors of foodborne pathogens in the Al-Qassim Region, Saudi Arabia.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, 51452 P.O. Box 6666, Saudi Arabia.
Foodborne illnesses pose a significant public health threat globally, particularly in Saudi Arabia, where the rapid growth of the food service sector has increased the risk of exposure to multidrug-resistant (MDR) bacteria. Traditional microbiological methods are often time-consuming and may lack precision, highlighting the need for faster and more accurate diagnostic alternatives. In this study, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) was employed for the rapid and precise identification of bacterial contaminants in ready-to-eat (RTE) foods, alongside an assessment of their antibiotic resistance profiles.
View Article and Find Full Text PDFAmoxicillin-Clavulanic Acid-Induced Rash in Epstein-Barr Virus Infection: A Case Report of a Diagnostic Pitfall in a 24-Year-Old Male.
Cureus
July 2025
Infectious Diseases, Globalmed University Clinic, Tbilisi, GEO.
Infectious mononucleosis (IM), caused by the Epstein-Barr virus (EBV), is primarily a self-limiting illness. However, it often mimics bacterial infections, such as bacterial tonsillitis, which can represent a diagnostic pitfall and, consequently, increase the risk of developing complications. The aim of this case report is to highlight the complications resulting from the incorrect differential diagnosis of EBV-induced IM and its clinical significance.
View Article and Find Full Text PDFPO-llution control: a cross-sectional study on the role of antimicrobial stewardship in reducing healthcare's carbon footprint.
JAC Antimicrob Resist
August 2025
Department of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland.
Objectives: To evaluate the environmental impact of prolonged IV antimicrobial courses and identify opportunities for improved antimicrobial stewardship (AMS) practices.
Methods: A retrospective cross-sectional study was conducted using AMS ward-round data from January 2023 to December 2024 at a tertiary hospital in Dublin, Ireland. Data on IV antimicrobial prescriptions, AMS recommendations for discontinuation or IV to oral switch (IVOS) and prescriber acceptance were reviewed.
A Cross-Sectional Study of Extended-Spectrum -Lactamase-Producing Isolated From Clinical Samples: Single-Center Investigation in Indonesia.
Int J Microbiol
August 2025
Department of Medical Laboratory Sciences, Jimma University, Jimma, Oromia, Ethiopia.
The emergence of extended-spectrum beta-lactamase-producing (ESBL-producing ) is a significant public health concern, particularly in developing countries like Indonesia, where reports on the prevalence and characteristics of these resistant strains are scarce. This lack of data hampers effective infection control and antibiotic stewardship efforts. This study is aimed at investigating the prevalence and assessing the antimicrobial susceptibility profiles of ESBL-producing isolated from clinical samples of Indonesian patients, thereby contributing to an understanding of antibiotic resistance patterns in this region.
View Article and Find Full Text PDFChildren with confirmed nonimmediate allergic reactions to beta-lactam antibiotics can develop tolerance after a long period of drug avoidance.
Pediatr Allergy Immunol
September 2025
Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
Background: Allergic reactions to beta-lactam antibiotics (βLs) can fade over time, the length of which depends on the effector mechanism and the culprit drug. Most studies investigating this subject included people with immediate reactions (IRs). There is little evidence on (T-cell dependent) non-immediate reactions (NIRs), particularly in children.
View Article and Find Full Text PDF