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A Dimer Coagulation, Isolation and Coalescence (DCIC) technique is used to probe the phase behaviour and glass transition temperatures of ternary aerosol mixtures. The DCIC technique is used to perform temperature and relative humidity dependent viscosity measurements at viscosities near 5 × 106 Pa s. Measurements include organic-organic and organic-inorganic mixtures composed of sucrose-citric acid and sucrose-sodium nitrate. The data reported here add additional insight into the wide discrepancies in glass transition temperatures reported for pure sodium nitrate. The phase diagram model used in the work of Rothfuss and Petters (Phys. Chem. Chem. Phys., 2017, 19, 6532-6545) is expanded to include multiple solute components. Data and model predictions of the mixtures are in good agreement with the modified model. These measurements are compared with values from Holographic Optical Tweezer (HOT) measurements taken at room temperature. Overall, the viscosities determined from the DCIC and HOT techniques are in good agreement.
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http://dx.doi.org/10.1039/c8cp00760h | DOI Listing |
Mol Cell Proteomics
July 2025
PCCSE, Department of Genome Sciences, University of Washington, Seattle, Washington, USA. Electronic address:
The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that are potentially disruptive to cells. Because of the importance of proteins and their modifications to the response of specific cellular perturbations, four of the six LINCS centers have included significant proteomics efforts in the characterization of the resulting phenotype. This manuscript aims to describe this effort and the data harmonization and integration of the LINCS proteomics data discussed in recent LINCS papers.
View Article and Find Full Text PDFMed Sci Monit
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
BACKGROUND The precedence effect (PE) is a physiological phenomenon for accurate sound localization in a reverberant environment. Physiological studies of PE have mostly focused on the central nucleus of the inferior colliculus (CNIC), which receives ascending and descending projections, as well as projections from the shell of the inferior colliculus (IC) and contralateral IC. However, the role of the dorsal cortex of the IC (DCIC), which receives ascending and descending projections to ensure sound information processing and conduction on PE formation, remains unclear.
View Article and Find Full Text PDFAnn Rheum Dis
September 2024
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Objectives: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort.
Methods: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treatment: clinical (c) SLEDAI-2K=0, without prednisone/immunosuppressants; (2) remission on-treatment: cSLEDAI-2K=0, prednisone ≤5 mg/day and/or maintenance immunosuppressants; (3) LDA-Toronto Cohort (TC): cSLEDAI-2K≤2, without prednisone/immunosuppressants; (4) modified lupus LDA state (mLLDAS): SLEDAI-2K≤4, no activity in major organs/systems, no new activity, prednisone ≤7.
J Surg Res
December 2022
Andrews Academic Tower, Oklahoma City, Oklahoma.
Introduction: Need for discharge to intermediate care (DCIC) can increase length of stay and be a source of stress to patients. Estimating risk of DCIC would allow earlier involvement of case managers, improve length of stay and patient satisfaction by setting realistic expectations. The aim was to use National Surgical Quality Improvement Program dataset to develop a prediction model for DCIC after undergoing liver metastasectomy.
View Article and Find Full Text PDFCurr Protoc
July 2022
Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
The Library of Integrated Network-based Cellular Signatures (LINCS) was an NIH Common Fund program that aimed to expand our knowledge about human cellular responses to chemical, genetic, and microenvironment perturbations. Responses to perturbations were measured by transcriptomics, proteomics, cellular imaging, and other high content assays. The second phase of the LINCS program, which lasted 7 years, involved the engagement of six data and signature generation centers (DSGCs) and one data coordination and integration center (DCIC).
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