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Soil erosion by water is critical for soil, lake and reservoir degradation in the mid-hills of Nepal. Identification of the nature and relative contribution of sediment sources in rivers is important to mitigate water erosion within catchments and siltation problems in lakes and reservoirs. We estimated the relative contribution of land uses (i.e. sources) to suspended and streambed sediments in the Chitlang catchment using stable carbon isotope signature (δC) of long-chain fatty acids as a tracer input for MixSIAR, a Bayesian mixing model used to apportion sediment sources. Our findings reveal that the relative contribution of land uses varied between suspended and streambed sediment, but did not change over the monsoon period. Significant over- or under-prediction of source contributions could occur due to overlapping source tracer values, if source groups are classified on a catchment-wide basis. Therefore, we applied a novel deconvolutional framework of MixSIAR (D-MixSIAR) to improve source apportionment of suspended sediment collected at tributary confluences (i.e. sub-catchment level) and at the outlet of the entire catchment. The results indicated that the mixed forest was the dominant (41 ± 13%) contributor of sediment followed by broadleaf forest (15 ± 8%) at the catchment outlet during the pre-wet season, suggesting that forest disturbance as well as high rainfall and steep slopes interact for high sediment generation within the study catchment. Unpaved rural road tracks located on flat and steep slopes (11 ± 8 and 9 ± 7% respectively) almost equally contributed to the sediment. Importantly, agricultural terraces (upland and lowland) had minimal contribution (each <7%) confirming that proper terrace management and traditional irrigation systems played an important role in mitigating sediment generation and delivery. Source contributions had a small temporal, but large spatial, variation in the sediment cascade of Chitlang stream. D-MixSIAR provided significant improvement regarding spatially explicit sediment source apportionment within the entire catchment system. This information is essential to prioritize implementation measures to control erosion in community managed forests to reduce sediment loadings to Kulekhani hydropower reservoir. In conclusion, using compound-specific stable isotope (CSSI) tracers for sediment fingerprinting in combination with a deconvolutional Bayesian mixing model offers a versatile approach to deal with the large tracer variability within catchment land uses and thus to successfully apportion multiple sediment sources.
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http://dx.doi.org/10.1016/j.scitotenv.2018.04.394 | DOI Listing |
Urol J
September 2025
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, TURKIYE.
Purpose: This study aimed to investigate the genetic heterogeneity of primary monosymptomatic nocturnal enuresis (PMNE) and assess potential genetic variants contributing to its etiology.
Materials And Methods: A total of 92 children aged 5-15 years with a positive family history of PMNE were evaluated. All patients underwent detailed urological and nephrological assessments to exclude organic causes.
World J Surg Oncol
September 2025
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan Dongcheng District, Beijing, 100730, China.
Purpose: We reviewed recent advancements in the characterization of intraductal oncocytic papillary neoplasm (IOPN) of the pancreas, with a specific focus on developments in immunohistochemical markers, molecular pathology, and pathogenic mechanisms over the past ten years (2015-2024). Through comprehensive analysis of current literature, we aimed to elucidate the evolving understanding of IOPN's biological behavior and diagnostic features, while identifying potential areas for future research in this distinctive pancreatic neoplasm.
Methods: English-language articles on IOPN were searched from Pubmed from the first report of IOPN of the pancreas in 2015 to 2024.
Mol Psychiatry
September 2025
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK.
Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We have also found decreases in hippocampal GABA receptors containing the α5 subunit (GABARα5) in a well-validated neurodevelopmental rat model of relevance for schizophrenia.
View Article and Find Full Text PDFBr J Cancer
September 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.
Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.
Biochim Biophys Acta Mol Cell Res
September 2025
University of Warsaw, Faculty of Biology, Institute of Experimental Plant Biology and Biotechnology, Department of Plant Metal Homeostasis, 1 Miecznikowa Str., 02-096, Warszawa, Poland. Electronic address:
The Natural Resistance Associated Macrophage Proteins (NRAMPs) are membrane-targeted transporters with low substrate specificity, that mediate the import (translocation to the cytoplasm) of metals, mainly essential nutrients, e.g. iron (Fe), manganese (Mn), zinc (Zn), cobalt (Co), copper (Cu) or nickel (Ni).
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