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http://dx.doi.org/10.1016/j.ijsu.2018.04.056 | DOI Listing |
Asia Pac J Clin Oncol
September 2025
Roche Products India Pvt. Ltd, Mumbai, India.
Introduction: Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, targets tumor cells overexpressing human epidermal growth factor receptor 2 (HER2). This single-arm, phase IV study assessed the safety and efficacy of T-DM1 in Indian patients with HER2-positive, locally advanced, or metastatic breast cancer previously treated with trastuzumab and a taxane.
Methods: Patients received T-DM1 (3.
BMJ Open
September 2025
Salisbury NHS Foundation Trust, Salisbury, UK.
Introduction: Difficulty with walking can lead to reduced quality of life for people with Parkinson's disease (pwPD); improving walking is considered a treatment priority. Drug therapies can control PD symptoms; however, pwPD often still experience mobility problems.Functional electrical stimulation (FES) induces movement in weak muscles via external electrical stimulation.
View Article and Find Full Text PDFDysphagia
September 2025
IRCCS Fondazione Don Carlo Gnocchi Onlus, Via di Scandicci, 269, Florence, 50143, Italy.
Unlike what is observed in the adult population, in paediatric rehabilitation, no reliable and validated observational tools are available in the Italian language to evaluate subjects considered to be at risk for swallowing disorders, regardless of the pathology. The aim of this study was to adapt the Mealtime Assessment Scale (MAS) to a paediatric population. Additionally, internal consistency, intra-rater and inter-rater agreement, concurrent validity and discriminative ability were investigated to assess validity and reliability of the scale.
View Article and Find Full Text PDFBlood
September 2025
University of Virginia Cancer Center, Charlottesville, Virginia, United States.
Histone deacetylase inhibitors (HDACi) are valued treatment options for patients with T-cell malignancies. Romidepsin is a selective Class I HDACi initially approved for patients with relapsed or refractory (R/R) CTCL and PTCL. Romidepsin was withdrawn from its PTCL indication following a negative randomized Phase IV study (Ro-CHOP) that showed no benefit over CHOP alone, further diminishing options for patients.
View Article and Find Full Text PDFExpert Opin Drug Discov
September 2025
First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Despite advances in antidepressant development, many patients with major depressive disorder (MDD) remain inadequately treated. Gepirone, a selective 5-HT1A agonist without reuptake inhibition, offers a novel mechanism potentially improving efficacy and tolerability over selective serotonin reuptake inhibitors (SSRIs) and earlier agents.
Areas Covered: This case history describes gepirone's discovery and development, including its pharmacodynamic profile, preclinical data on pharmacology, mechanism of action, and effects on depressive-like behavior and anxiety, as well as early clinical findings on its safety and efficacy in major depressive disorder.