98%
921
2 minutes
20
Background: Body weight (BW) is a relevant metric in emergency care. However, visual/physical methods to estimate BW are unreliable. We have developed a method for estimating BW based on effective mAs (mAs) from computed tomography (CT) dose modulation.
Methods: The mAs of CT examinations was correlated with the BW of 329 decedents. Linear regression analysis was used to calculate an equation for BW estimation based on the results of decedents with a postmortem interval (PMI) < 4 days (n = 240). The equation was applied to a validation group of 125 decedents. Pearson correlation and -test statistics were used.
Results: We found an overall strong correlation between mAs and BW ( = 0.931); values ranged from 0.854 for decedents with PMI ≥ 4 days to 0.966 for those with PMI < 4 days; among the latter group, was 0.974 for females and 0.960 for males and 0.969 in the presence and 0.966 in the absence of metallic implants (all correlations with values < 0.001). The estimated BW was equal to 3.732 + (0.422 × mAs) - (3.108 × sex index), where the sex index is 0 for males and 1 for females. The validation group showed a strong correlation ( = 0.969) between measured BW and the predicted BW, without significant differences overall ( = 0.119) as well as in female ( = 0.394) and in male decedents ( = 0.196). No outliers were observed.
Conclusions: CT dose modulation is a rapid and reliable method for BW estimation with potential use in clinical practice, in particular in emergency settings.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909357 | PMC |
http://dx.doi.org/10.1186/s41747-017-0028-z | DOI Listing |
Biom J
October 2025
Novella Clinical Full Service, IQVIA, Melbourne, Australia.
Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular-targeted therapies and antibody drug conjugates, dose-limiting toxicities are less frequently observed, giving rise to the concept of optimal biological dose (OBD), which considers both efficacy and toxicity. The estimand framework presented in the addendum of the ICH E9(R1) guidelines strengthens the dialogue between different stakeholders by bringing in greater clarity in the clinical trial objectives and by providing alignment between the targeted estimand under consideration and the statistical analysis methods.
View Article and Find Full Text PDFAnim Sci J
January 2025
Faculty of Agriculture, Iwate University, Morioka, Japan.
Hardness of meat is one of the most important textural properties noted while eating. Bromelain, found in pineapples, is an enzyme that degrades collagen, a factor that affects meat hardness. The latter is generally evaluated based on shear strength and texture; however, such methods are destructive.
View Article and Find Full Text PDFWounds
August 2025
Department of Nursing, Federal University of Ceará, Ceará, Brazil.
Background: To estimate the prevalence of biofilms in chronic wounds.
Methods: The authors performed a systematic review of prevalence studies and meta-analysis, structured according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Articles were searched in Scopus (Elsevier), Web of Science (Clarivate), MEDLINE/PubMed (National Institutes of Health), and Embase (Elsevier) databases.
BJOG
September 2025
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM).
Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial.
Setting: Sweden, with risk-factor based screening for GDM.
BMC Nurs
September 2025
Department of Nursing Administration, Faculty of Nursing, Alexandria University, Alexandria, Egypt.
Background: Organizational virtuousness and just culture, which both foster justice, honesty, and trust, have a major impact on positive work environments in the healthcare industry. Strengthening nurses' emotional engagement and vocational commitment requires these components. With an emphasis on the mediating function of just culture, this study attempts to investigate the relationship between organizational virtuousness and nurses' vocational commitment.
View Article and Find Full Text PDF