Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The aim of this study was to determine if weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of the renin angiotensin system (RAS), catecholamines and endothelin-1, and also with an increase in the concentrations of vasodilators. Fasting blood samples were obtained from 15 patients with morbid obesity and diabetes prior to and 6 months after RYGB surgery. Circulating levels of neprilysin, vasoconstrictors, vasodilators, and the mRNA expression of related genes in circulating mononuclear cells (MNC) were measured. Six months after RYGB surgery the concentrations of neprilysin, angiotensinogen, angiotensin II, renin and endothelin-1 fell significantly by 27 ±16%, 22 ±10%, 22 ±8%, 35 ±13% and 17 ±6% (P < .05 for all), respectively, while ANP concentrations increased significantly by 24 ±13%. There was no significant change in aldosterone, BNP, cAMP or cGMP concentrations, or angiotensin converting enzyme (ACE) expression. These changes may contribute to the reduction of congestive cardiac failure and blood pressure risks after RYGB surgery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/dom.13320 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Strategies for Conservative Management of Early Post-Operative Obstruction Following Roux-en-Y Gastric Bypass.
Obes Surg
September 2025
Department of Surgery, New York University Grossman School of Medicine; Bellevue Hospital, New York, United States.
Background: Early postoperative small bowel obstruction (ESBO) following roux-en-Y gastric bypass (RYGB) is a feared complication, generally estimated to occur in 1-2% of cases. Most surgeons advocate for prompt surgical exploration for ESBO after RYGB. There is currently a paucity of literature regarding conservative management approaches to ESBO after RYGB.
View Article and Find Full Text PDFEffects of diet-induced weight loss and Roux-en-Y gastric bypass on the glycemic and gut hormones profile in patients with severe obesity and diabetes.
Clinics (Sao Paulo)
September 2025
Hospital das Clinicas (HC), Universidade de Sao Paulo (USP), São Paulo, SP, Brazil.
Objectives: The mechanisms following glycemic control after RYGB are still not fully elucidated. The objective of the present study was to compare the effects of similar weight loss induced by a Very Low Calorie Diet (VLCD) and by Roux-en-Y Gastric Bypass (RYGB) on the glycemic and gut hormone profile in patients with severe obesity and T2DM.
Methods: A prospective controlled observational study with 10 patients evaluated before (pre-0), after 10 % weight loss induced by VLCD (pre-1), and after 10 % weight loss induced by RYGB (post).
Pregnancy Outcomes Following Different Types of Bariatric Surgery: A Network Meta-Analysis.
Obes Surg
September 2025
Obstetrical Department, Affiliated Maternity and Child Health Care Hospital of Nantong University, nantong, China.
The increasing number of women of reproductive age undergoing bariatric surgery has brought more attention to pregnancies following these procedures. However, the impact of different types of bariatric surgery on pregnancy outcomes remains unclear. This study aims to systematically investigate the effects of four types of bariatric surgery-Roux-en-Y gastric bypass (RYGB), laparoscopic adjustable gastric banding (LAGB), sleeve gastrectomy (SG), and biliopancreatic diversion (BPD)-on pregnancy outcomes.
View Article and Find Full Text PDFSurgical management of marginal ulcer sequelae after Roux-en-Y gastric bypass: a single-center retrospective cohort study.
Surg Endosc
September 2025
Division of Advanced Gastrointestinal and Bariatric Surgery, Department of General Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Background: Marginal ulcer (MU) is a rare complication following Roux-en-Y Gastric Bypass (RYGB). If left untreated, MU can progress into severe sequelae, including ulcer stenosis, gastrogastric fistula (GGF), or perforation. The aim of this study is to describe the surgical management for each of the three types of MU sequelae and to evaluate the risk of ulcer recurrence and the impact on weight loss following Revisional Bariatric Surgery (RBS).
View Article and Find Full Text PDFWeight loss following gastric bypass increases aldosterone reactivity to orthostatic stress in patients with obesity.
Blood Press
September 2025
Service of nephrology and hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Background: Weight loss after gastric bypass is associated with blood pressure reduction. However, the precise role of the sympathetic nervous system and renin-angiotensin-aldosterone system in this reduction remains unclear. We investigated the effect of RYGB-induced weight loss on the hemodynamic, hormonal, and renal responses to an orthostatic stress induced by lower body negative pressure (LBNP).
View Article and Find Full Text PDF