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Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.
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Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA.
Dysregulated spine morphology is a common feature in the pathology of many neurodevelopmental and neuropsychiatric disorders. Overabundant immature dendritic spines in the hippocampus are causally related to cognitive deficits of Fragile X syndrome (FXS), the most common form of heritable intellectual disability. Recent findings from us and others indicate autophagy plays important roles in synaptic stability and morphology, and autophagy is downregulated in FXS neurons.
View Article and Find Full Text PDFSleep disorders in children with neurodevelopmental disorders: Comparative actigraphy and questionnaire assessment in ASD, ADHD, and controls.
Sleep Med
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Regional Epilepsy Center, Operative Unit of Childhood and Adolescent Neuropsychiatry, ASST Spedali Civili di Brescia, Brescia, Italy.
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Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis.
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Perinatal Epidemiology Group, Department of Obstetrics, Gynaecology, and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia.
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Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome.
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Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluated the therapeutic potential of a circadian-based intervention in the fragile X mental retardation 1 () knockout (KO) mouse. The KO mice exhibited fragmented sleep, impaired locomotor rhythmicity, and attenuated behavioral responses to light, linked to an abnormal retinal innervation and reduction of light-evoked neuronal activation in the suprachiasmatic nucleus.
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The Central Lab, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.
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