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Targeting PAR-2 in atopic dermatitis: Preclinical evaluation of the novel inhibitor E6795.
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Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; A∗STAR Skin Research Labs (A∗SRL), Skin Research Institute of Singapore (SRIS), Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A∗STAR), 8A Biomedical Grove, IMMUNOS Buildi
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and compromised skin barrier function. Despite the advent of new therapeutics, many individuals still face insufficient disease control, high costs, and relapse. Protease-activated receptor 2 (PAR-2), overexpressed in AD lesions, plays a central role in promoting inflammation, itch, and alterations in epidermal homeostasis.
View Article and Find Full Text PDFReducing ocular using petroleum jelly may alleviate dry eye syndrome, blepharitis, facial dermatoses, ocular and respiratory allergies, and decrease associated prescribing: a hypothesis.
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Independent Research Pharmacist, Cardiff, United Kingdom.
eyelash mites are increasingly associated with eye and skin inflammation in humans, and cause demodectic mange in mammals. Informal accounts of symptom improvement and reduced need for anti-allergy medicines, when reproduction is prevented, indicate a further role linking to rhinitis, asthma and dermatitis. Their mobility, allergenic debris and consequential immunological impact may also explain progression of allergies in the .
View Article and Find Full Text PDFPsychosocial interventions for children with dermatological conditions: systematic review and meta-analysis.
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Dermatology Service, Children's Health Queensland Hospital and Health Service, South Brisbane, QLD, Australia.
Objective: Chronic skin conditions contribute to psychosocial difficulties and reduced child/parent quality of life, impacting condition management and disease control. The objective of this systematic review was to summarize the literature on psychosocial interventions (interventions that therapeutically target psychological/social processes to improve outcomes) for children with chronic dermatological conditions and their families.
Methods: Searches of five electronic databases (CINAHL, PubMed, PsycINFO, Scopus, The Cochrane Library, Web of Science) identified relevant articles published from dates of inception to April 8, 2024, and reference lists were searched for additional relevant articles.
Idiopathic Anaphylaxis Grand Rounds.
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Department of Medicine, Division of Allergy and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Idiopathic anaphylaxis (IA) refers to recurrent, life-threatening hypersensitivity reactions without identifiable triggers, representing a diagnostic and therapeutic challenge. We describe a 17-year-old girl presenting with recurrent episodes of flushing, pruritus, and respiratory symptoms, without consistent allergen exposure or cofactor involvement. Evaluation revealed elevated acute tryptase levels with a normal baseline, negative skin testing, and negative alpha-gal and KIT mutation analysis.
View Article and Find Full Text PDFIL-15 Promotes the Survival of Anti-Inflammatory (M2), Immunoinhibitory (IL-10+) Dermal Macrophages in Human Eyelid Skin Under IFNγ-Dominated Inflammatory Conditions.
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Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33125, USA.
Interleukin (IL)-15 is primarily known as a pro-inflammatory and anti-apoptotic cytokine, which stimulates the proliferation and survival of key immunocytes, including macrophages (MACs). Yet, it remains unclear how IL-15 specifically impacts MACs in intact human skin, particularly immunoinhibitory, IL-10-producing/secreting M2 MACs (CD206IL-10). In the current pilot study, we explored this in organ-cultured healthy human eyelid skin in the presence of IFNγ (100 IU/mL) to mimic a pro-inflammatory signaling milieu found in several chronic immunodermatoses.
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