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Objective: To analyze the results of assessment and authentication of malaria elimination of 7 county-level cities and districts in Changzhou City, Jiangsu Province, and explore the suitable monitoring methods for malaria after the elimination in this region, so as to provide the evidence for formulating and adjusting the malaria elimination strategies and measures.
Methods: The data from the network reports of malaria epidemic situation, blood examinations of febrile patients, epidemiological questionnaires of malaria cases, investigation of epidemic focuses and disposal tables were collected and analyzed in Changzhou City from 2009 to 2014. The clinicians were assessed with the closed-book written examinations for their ability of the diagnosis and treatment of malaria. The inspection personnel were assessed by the microscopical examinations of . Totally 30 negative blood slides were reviewed. In the natural village where the last local case of malaria was located, 200 blood filter papers were collected for gene detection of .
Results: From 2009 to 2014, 145 malaria cases were reported in Changzhou City. Totally 170 638 febrile patients received blood detections for malaria, of which 137 cases were positive and the positive rate was 0.08%. The majority of malaria cases were imported except 8 local malaria infection cases in 2009 and 2 local malaria infection cases in 2010. Four of seven county-level cities (districts) gained an average score of 20 points on the microscopical examinations of . Liyang City got a minimum average score of 18.8 points. In capacity assessment of malaria diagnosis and treatment, Liyang City gained the highest average score of 19.8 points, and Qishuyan District got the lowest average score of 18.0 points. The malaria elimination assessment scores of the 7 county-level cities (districts) were all above 93 points. Four county-level cities (districts) (Xinbei District, Wujin District, Liyang City, and Jintan City) carried out the active case detections. A total of 731 cases were detected and the results were all negative. Liyang City in 2012, Zhonglou District and Jintan City in 2013, Tianning District, Qishuyan District, Xinbei District and Wujin District in 2014, passed the malaria elimination assessment at county (district) level, respectively.
Conclusions: All the 7 county-level cities (districts) of Changzhou City have passed the malaria elimination assessment at a high score. After the malaria elimination, the monitoring should continue to consolidate the achievements.
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http://dx.doi.org/10.16250/j.32.1374.2016011 | DOI Listing |
J Infect Dis
September 2025
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Background: Brazil's progress toward malaria elimination has stalled and 163,000 new cases (more than 80% caused by Plasmodium vivax) were recorded in the Brazilian Amazon in 2023. We hypothesize that human mobility continues to disperse parasites from hotspots to areas with decreasing endemicity.
Methods: We analyzed 5.
PLoS Negl Trop Dis
September 2025
School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
Direct morbidity assessments are rarely included in monitoring and evaluation of Schistosoma mansoni mass drug administration programmes. This is despite morbidity reduction being the leading objective of control and elimination as a public health problem in the World Health Organization (WHO) targets. Instead, the number of eggs-per-gram (EPG) of faeces are used as a morbidity proxy.
View Article and Find Full Text PDFJ Parasit Dis
September 2025
Department of Medical Laboratory Technology, School of Medical Sciences, Accra Technical University, Accra, Ghana.
The host immune response to malaria is a complex interplay between the parasite, Plasmodium, and the human immune system. Upon infection, various components of the immune system, including innate and adaptive responses, are mobilized to combat the parasite. Innate immunity provides the initial defense, with cells such as macrophages, dendritic cells, and natural killer cells recognizing and responding to the parasite.
View Article and Find Full Text PDFMalar J
September 2025
Kenya Medical Research Institute, Wellcome Trust Research Program, P.O. Box 230-80108, Kilifi, Kenya.
Background: Characterizing malaria epidemiology at the local level requires understanding the diverse malaria vector species driving transmission, including both primary and secondary vectors. Effective mosquito surveillance and accurate species identification are critical; however, due to the associated cost and complexity, most surveillance strategies mainly focus on the primary malaria vectors. There is a need for cost-effective methods that can reliably identify both primary and secondary vectors as their role in transmission becomes increasingly important while reaching towards elimination.
View Article and Find Full Text PDFmedRxiv
August 2025
Department of Microbiology and Immunology, Bio21 Institute and Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Current interventions targeting malaria control in sub-Saharan Africa (SSA) are focused on , the most prevalent species infecting humans. Despite renewed efforts for malaria elimination in SSA, little attention has been paid to the neglected parasites and spp. and the impact of interventions like long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS) with non-pyrethroid insecticides, and/or seasonal malaria chemoprevention (SMC) on these minor spp.
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