Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ctcp.2017.11.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
New Indazole Derivatives as Potential Scaffolds for the Development of Anticancer, Antiviral, and Anti-tuberculosis Chemotherapeutic Compounds.
Curr Med Chem
September 2025
Laboratory of Molecular Basis of Action of physiologically active compounds, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.
Introduction: Chemotherapy remains essential despite advances in immunotherapy, radiotherapy, and biological therapy. However, the wide range of chemical drugs is limited by a narrow therapeutic index, low selectivity, and the development of resistance. In this regard, new high-efficiency drugs are in extremely high demand.
View Article and Find Full Text PDFSynthesis, Characterization, and Antimicrobial Evaluation of Some Novel Hydrazinecarbothioamides.
Turk J Pharm Sci
September 2025
İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Türkiye.
Objectives: This study focused on synthesizing and characterizing novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety and evaluating their antimicrobial activity against several bacterial strains. The research aimed to identify key structural features that enhance antimicrobial efficacy through structure-activity relationship analysis and identify the minimum inhibitory concentration (MIC) of the most potent compounds to assess their potential for further development as antimicrobial agents.
Materials And Methods: Nine novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety were synthesized by reacting 1,2,4-triazole derivatives with thiosemicarbazide precursors, and the products were characterized using infrared spectroscopy, proton nuclear magnetic resonance (H-NMR), carbon-13 nuclear magnetic resonance (C-NMR) spectroscopy, and elemental analysis.
Antibacterial mode of action of thyme white (Thymus vulgaris L.) essential oil and its constituents, thymol and carvacrol against Agrobacterium tumefaciens via down-regulation of manganese transport genes, sitABCD and mntH.
Pestic Biochem Physiol
November 2025
Department of Agriculture, Forestry and Bioresources, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of
In this study, we evaluated the antibacterial activities of plant essential oils (EOs) from the Lamiaceae family against Agrobacterium tumefaciens to find new eco-friendly antimicrobials. Thymus vulgaris L. (thyme white) EO demonstrated the most potent fumigant antibacterial activity among these.
View Article and Find Full Text PDFDevelopment of Novel Cefoperazone-Loaded Glycerosomes for Enhanced Wound Healing and Antibacterial Efficacy: In Vitro and In Vivo Assessments.
J Pharm Sci
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Bacterial burn wound infections can disrupt the natural wound-healing process, leading to life-threatening diseases. This study aimed to investigate the use of glycerosomes as a novel system for the topical delivery of cefoperazone to promote its burn wound healing action. Cefoperazone-loaded glycerosomes (CEFO-GLY) were optimized using a 2 full-factorial design and prepared via the thin film hydration method.
View Article and Find Full Text PDFQuaternary ammonium chitosan/N-isopropylacrylamide-based Janus hydrogel with asymmetric adhesive, shrinkable, and antimicrobial properties for wound healing.
Int J Biol Macromol
September 2025
School of Chemical Engineering, Sichuan University, Chengdu, 610065, PR China. Electronic address:
Conventional wound dressings primarily focus on biochemical regulation, often neglecting the potential benefits of mechanical cues in tissue regeneration. We report a Janus hydrogel (QPJ hydrogel) that synergistically integrates biochemical modulation with temperature-responsive mechanical contraction for advanced chronic wound management. The hydrogel is constructed from quaternary ammonium chitosan (QCS) and N-isopropylacrylamide (NIPAM), with an outer PNIPAM layer that generates a directional contractile stress >25 kPa at physiological temperature.
View Article and Find Full Text PDF