Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of concept, codelivery of CO with the antibiotic metronidazole was demonstrated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.7b03348 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systemic Delivery of an mRNA-Encoding, Tumor-Activated Interleukin-12 Lock to Eliminate Tumors and Avoid Immune-Related Adverse Events.
Nano Lett
September 2025
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.
Interleukin-12 (IL-12) is a robust proinflammatory cytokine that activates immune cells, such as T cells and natural killer cells, to induce antitumor immunity. However, the clinical application of recombinant IL-12 has been limited by systemic immune-related adverse events (irAEs) and rapid degradation. To address these challenges, we employed mRNA technology to encode a tumor-activated IL-12 "lock" fusion protein that offers both therapeutic efficacy and systemic safety.
View Article and Find Full Text PDFWater Adsorption in Metal-Organic Frameworks: Characteristics, Mechanisms, and Structure-Property Relationships.
J Am Chem Soc
September 2025
Department of Chemical Engineering, National Taiwan University, Taipei 106319, Taiwan.
To address the increasingly limited water availability, using metal-organic frameworks (MOFs) to capture atmospheric water vapor as usable resources has emerged as a promising strategy. The adsorption characteristics of MOFs as well as their step pressure (i.e.
View Article and Find Full Text PDFElectronegativity-Induced Jahn-Teller Distortion Boosts Li-S Conversion on Asymmetric Cu Single-Atom Catalysts.
J Phys Chem A
September 2025
Department of Chemistry, Tsinghua University, Beijing 100084, China.
A series of Cu-based single-atom catalysts (SACs) with asymmetric coordination were designed to accelerate lithium-sulfur (Li-S) chemistry. The electronegativity contrast from the dopant induces a localized electronic asymmetry that amplifies Jahn-Teller distortion at the Cu center. This distortion profoundly modulates the Cu 3d electronic structure and its interaction with Li-S intermediates.
View Article and Find Full Text PDFDual and Single-species Nematode Infections Distinctly Modulate Defense Metabolism in Brassica nigra Roots.
J Chem Ecol
September 2025
Leibniz Institute for Vegetable and Ornamental Crops (IGZ) e.V., Großbeeren, Germany.
Plant roots are exposed to various organisms that significantly impact plant productivity. Plant-parasitic nematodes (PPNs) such as Meloidogyne spp. and Pratylenchus spp.
View Article and Find Full Text PDFAlkali chalcogenides-assisted vapor-liquid-solid growth of WX (X = S, Se, Te).
Discov Nano
September 2025
Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Promoter-assisted chemical vapor deposition (CVD) has emerged as a robust strategy for the low-temperature synthesis of diverse transition metal dichalcogenides (TMDs). In these processes, promoter-induced intermediates facilitate specific reaction pathways, enabling controlled growth via vapor-solid-solid (VSS) or vapor-liquid-solid (VLS) modes. While previous studies have primarily focused on transition metal precursors, growth pathways involving engineered chalcogen-based intermediates remain underexplored due to their volatility and low melting points.
View Article and Find Full Text PDF