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Involvement of endolysosome iron in HIV-1 gp120-, morphine-, and iron supplementation-induced disruption of the reactive species interactome and induction of neurotoxicity.
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Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.
Background: Iron continues to be linked to the pathogenesis of neurodegenerative disorders including HIV-1 associated neurocognitive disorders (HAND). People with HIV-1 who use opioids have a higher risk of developing HAND, and HIV-1 proteins and opioids disrupt endolysosome iron homeostasis, increase reactive oxygen species (ROS), and cause neural cell death. Endolysosomes are subcellular acidic organelles that regulate iron metabolism and redox homeostasis.
View Article and Find Full Text PDFMechanisms underlying the role of FeO in enhancing antibiotic degradation and mitigating the spread of antibiotic resistance in aquaculture sediment: Coupling dissimilatory iron reduction with methanogenesis.
J Hazard Mater
August 2025
Department of Environmental Engineering, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing 210095, China. Electronic address:
Ferric oxides play a critical role in transforming organic contaminants within anaerobic aquaculture sediments; however, their effect on the removal of antibiotics and antibiotic resistance genes (ARGs) remains unexplored. This study revealed that the addition of FeO significantly promoted microbial Fe(III) reduction, SMX degradation, and methanogenesis by enhancing metabolic activity and facilitating electron transfer. While nutrient supplementation similarly improved SMX removal, it notably increased ARG abundance, unlike FeO, which effectively suppressed ARGs.
View Article and Find Full Text PDFExogenous iron caused osteocyte apoptosis, increased RANKL production, and stimulated bone resorption through oxidative stress in a murine model.
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Department of Spine Surgery, People's Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen, China; Department of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China. Electronic address:
Iron overload is a risk factor for osteoporosis due to its oxidative toxicity. Previous studies have demonstrated that an excessive amount of iron increases osteocyte apoptosis and receptor activator of nuclear factor κ-B ligand (RANKL) production, which stimulates osteoclast differentiation in vitro. However, the effects of exogenous iron supplementation-induced iron overload on osteocytes in vivo and its role in iron overload-induced bone loss are unknown.
View Article and Find Full Text PDFIdentification of Genes Responding to Iron or Choline Treatment for Early-Life Iron Deficiency in the Male Rat Hippocampal Transcriptomes.
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Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States. Electronic address:
Background: Developmental iron deficiency (ID) is associated with long-term cognitive and affective behavioral impairments in humans. Preclinical studies have shown that developmental ID has short- and long-term effects on gene regulation. Prenatal choline supplementation partially rescues early-life ID-induced cognitive deficits in adult male rats.
View Article and Find Full Text PDFThe effects of intracellular iron availability on the outcome of infection in mice.
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September 2023
Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
( parasite that obtains the iron it needs for its own metabolism from the host-cell iron pool. In this work, we aimed to investigate if iron supplementation or deficiency affected the course of infection. Eighty mice were divided into four groups, each with 20 animals: Group (I): Uninfected control group.
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