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Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.
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http://dx.doi.org/10.2169/internalmedicine.9144-17 | DOI Listing |
Cureus
July 2024
Dermatology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.
Myeloid sarcoma (MS) represents a neoplastic proliferation characterized by immature myeloid precursor cells. Among its variants, aleukemic MS is an uncommon subtype, manifesting as skin involvement sparing the peripheral blood or bone marrow. The non-specific cutaneous presentation coupled with the lack of associated symptoms poses a diagnostic challenge for providers.
View Article and Find Full Text PDFAnn Med Surg (Lond)
April 2024
Faculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.
Introduction And Importance: Myeloid sarcoma (MS) is a rare tumour associated with acute myeloid leukaemia (AML) and occasionally occurs independently. It typically affects skin, bone, lymph nodes, and rarely the gastrointestinal tract, with gastric cases being extremely rare. Notably, no reported instances associate pseudoachalasia with gastric myeloid sarcoma.
View Article and Find Full Text PDFInt J Hematol Oncol Stem Cell Res
October 2023
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Myeloid sarcoma (MS) or chloroma is a localized mass composed of blastic cells of granulocytic lineage. It is a subtype of acute myeloid leukemia and usually presents as a complication of acute myeloid leukemia, myeloid dysplastic syndrome, or myeloproliferative disorder. MS occurs in 2.
View Article and Find Full Text PDFJ Surg Case Rep
August 2023
Department of Urology at the Civitanova Marche Hospital, Civitanova Marche, Italy.
Myeloid sarcoma (MS) is an extramedullary tumor mass causing proliferation of mature or immature blast cells of one or more myeloid lineages. Involvement of the genitourinary tract is rare. We present a case of MS of the ureteral wall.
View Article and Find Full Text PDFMedicine (Baltimore)
October 2022
Department of Hematology, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Rationale: Myeloid sarcoma (MS) involves the proliferation of extramedullary blasts from 1 or more myeloid lineages, replacing the original tissue structures, and these neoplasias are called granulocytic sarcoma, chloroma, or extramedullary myeloid neoplasms. These tumors develop in lymphoid organs, bones, skin, soft tissues, various mucous membranes, organs, and the central nervous system. MS is rare in non-leukemic patients, while MS patient with effusion as the first manifestation is even rare.
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