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http://dx.doi.org/10.1097/MEG.0000000000001020 | DOI Listing |
Expert Rev Gastroenterol Hepatol
September 2025
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of conditions from simple steatosis to advanced fibrosis that may represent the cradle for hepatocellular carcinoma. Thus, an accurate assessment of fibrosis is critical for patient management. Noninvasive tools, including serum biomarkers and imaging techniques, have emerged as practical alternatives to liver biopsy, which presents limitations for invasiveness, cost, and sampling variability.
View Article and Find Full Text PDFEur J Heart Fail
September 2025
Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Aims: The estimated glucose disposal rate (eGDR) is a simple, non-invasive measure of insulin resistance. In this exploratory analysis of FINEARTS-HF, we evaluated whether lower eGDR, reflecting greater insulin resistance, is associated with adverse outcomes in heart failure (HF).
Methods And Results: The eGDR was calculated at baseline using waist circumference, glycated haemoglobin, and hypertension status.
Transl Stroke Res
September 2025
Department of Neurology, Aarhus University Hospital, Palle Juul Jensens Boulevard 165, Entrance J 518, 8200, Aarhus N, Aarhus, Denmark.
Remote ischemic conditioning (RIC) is a simple, non-invasive procedure that has been shown to be safe and feasible in multiple smaller clinical trials. Recent large randomized controlled trials have yielded mixed results regarding clinical effect. Patients with severe stroke may experience greater benefit from cerebroprotective interventions, highlighting the need for adjunctive therapies to enhance endovascular therapy (EVT) outcomes.
View Article and Find Full Text PDFUnlabelled: Dual-energy x-ray absorptiometry (DXA)-derived areal bone mineral density (BMD) remains the clinical standard for assessing osteoporosis risk, yet it fails to identify over 75% of individuals who sustain fragility fractures. Direct in vivo mechanical assessment of cortical bone strength may address this diagnostic gap by capturing structural and material properties that govern whole-bone strength but are not reflected by BMD. We conducted a multicenter case-control study with cross-sectional assessment to compare ulna flexural rigidity, a biomechanical property correlated with whole-bone strength (R² ≈ 0.
View Article and Find Full Text PDFFront Neurol
August 2025
Department of Traditional Chinese Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Background: With the growing global burden of ischemic stroke in aging populations, there is increasing interest in simple and non-invasive neurological markers to support early risk stratification and functional prognosis. Retroflex tongue (RT) and tongue deviation (TD) are observable signs of cranial nerve dysfunction; however, their comparative predictive value for stroke severity remains unclear.
Methods: In this retrospective observational study, 308 older adults (mean age: 69.