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In 2015, the United Nations (UN) issued probabilistic population projections for all countries up to 2100, by simulating future levels of total fertility and life expectancy and combining the results using a standard cohort component projection method. For the 40 countries with generalized HIV/AIDS epidemics, the mortality projections used the Spectrum/Estimation and Projection Package (EPP) model, a complex, multistate model designed for short-term projections of policy-relevant quantities for the epidemic. We propose a simpler approach that is more compatible with existing UN projection methods for other countries. Changes in life expectancy are projected probabilistically using a simple time series regression and then converted to age- and sex-specific mortality rates using model life tables designed for countries with HIV/AIDS epidemics. These are then input to the cohort component method, as for other countries. The method performed well in an out-of-sample cross-validation experiment. It gives similar short-run projections to Spectrum/EPP, while being simpler and avoiding multistate modelling.
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http://dx.doi.org/10.1080/00324728.2017.1401654 | DOI Listing |
PLoS One
September 2025
School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Background: Despite advances in HIV care, viral load suppression (VLS) among adolescents living with HIV (ALHIV) in Uganda continue to lag behind that of adults, even with the introduction of dolutegravir (DTG)-based regimens, the Youth and Adolescent Peer Supporter (YAPS) model, and community-based approaches. Understanding factors associated with HIV viral load non-suppression in this population is critical to inform HIV treatment policy. This study assessed the prevalence and predictors of viral load non-suppression among ALHIV aged 10-19 years on DTG-based ART in Soroti City, Uganda.
View Article and Find Full Text PDFJ Int Assoc Provid AIDS Care
September 2025
Department of Internal medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BackgroundDolutegravir (DTG)-based antiretroviral treatment is now the recommended regimen because of its high efficacy and fewer adverse effects. Nonetheless, hyperglycemia as adverse effect of DTG was reported in few clinical observations.MethodsA case-control study was carried out among DTG-based antiretroviral therapy (ART) users during the study period.
View Article and Find Full Text PDFAIDS Behav
September 2025
Department of Community Health and Social Sciences, City University of New York Graduate School of Public Health and Health Policy, New York, NY, USA.
Self-testing for HIV is an accessible, effective testing method for clinical and research contexts. From 2017 to 2022, we conducted annual, mail-in HIV testing with participants in our U.S.
View Article and Find Full Text PDFAnn Intern Med
September 2025
Johns Hopkins University School of Medicine, Baltimore, Maryland (M.S., J.J., K.A.G., M.S., A.T.F.).
Background: With antiretroviral therapy, people with HIV can live a normal lifespan and not transmit HIV. The Ryan White HIV/AIDS Program provides care for over half of people with HIV in the United States.
Objective: To estimate how many HIV infections could result from cessation of Ryan White services or interruptions lasting 18 to 42 months.
J Infect Dev Ctries
August 2025
Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Cameroon.
Introduction: Despite increased national and international funding to combat the human immunodeficiency virus (HIV) pandemic, prison health services remain underfunded, resulting in poor HIV management among inmates. This study assessed viral suppression rates among HIV-positive inmates across four central prisons in Cameroon to evaluate the effectiveness of antiretroviral therapy (ART) in these settings.
Methodology: This cross-sectional study included four central prisons-prisons A, B, C, and D-each located in different regions of Cameroon.