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The cover image, by Satoru Ikenoue et al., is based on the Clinical Report Discordant fetal phenotype of hypophosphatasia in two siblings, DOI: 10.1002/ajmg.a.38531.
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http://dx.doi.org/10.1002/ajmg.a.38585 | DOI Listing |
Gut Liver
September 2025
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Background/aims: Ampullary adenomas are precancerous lesions requiring accurate diagnosis and timely intervention to prevent malignant transformation. Endoscopic papillectomy (EP) has emerged as a less invasive alternative to surgery; however, technical variations in practice remain. This study evaluated contemporary real-world approaches to the diagnosis, treatment, and surveillance of ampullary adenomas among pancreatobiliary endoscopists.
View Article and Find Full Text PDFCell
September 2025
Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Baden-Württemberg 69117, Germany; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Metabolomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Baden-Württe
Single-cell metabolomics (SCM) promises to reveal metabolism in its complexity and heterogeneity, yet current methods struggle with detecting small-molecule metabolites, throughput, and reproducibility. Addressing these gaps, we developed HT SpaceM, a high-throughput SCM method combining cell preparation on custom glass slides, small-molecule matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (MS), and batch processing. We propose a unified framework covering quality control, characterization, structural validation, and differential and functional analyses.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Division of Nano Life Science, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa, Japan.
Atomic force microscopy (AFM) imaging of ionic liquid (IL) distribution in electric double-layer (EDL) devices has been actively explored to understand the origin of their excellent performance. However, this has been impeded by insufficient resolution or a poor understanding of the mechanisms of 3D IL imaging. Here, we overcome these difficulties using 3D scanning force microscopy (3D-SFM) with variable tip/sample bias voltages for visualizing 3D ,-diethyl--methyl--(2-methoxyethyl)ammonium bis(trifluoromethanesulfonyl)imide (DEME-TFSI) distributions on a Au electrode in EDL capacitors.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
September 2025
Department of Rhythmology, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, Lübeck, 23652, Germany.
Purpose: Ultrasound (US) is commonly used to assess left ventricular motion for examination of heart function. In stereotactic arrhythmia radioablation (STAR) therapy, managing cardiorespiratory motion during radiation delivery requires representation of motion information in computed tomography (CT) coordinates. Similar to conventional US-guided navigation during surgical procedures, 3D US can provide real-time motion data of the radiation target that could be transferred to CT coordinates and then be accounted for by the radiation system.
View Article and Find Full Text PDFProg Nucl Magn Reson Spectrosc
September 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom; School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile; Institute for Biological and Medical
Cardiovascular magnetic resonance (CMR) imaging is an established non-invasive tool for the assessment of cardiovascular diseases, which are the leading cause of death globally. CMR provides dynamic and static multi-contrast and multi-parametric images, including cine for functional evaluation, contrast-enhanced imaging and parametric mapping for tissue characterization, and MR angiography for the assessment of the aortic, coronary and pulmonary circulation. However, clinical CMR imaging sequences still have some limitations such as the requirement for multiple breath-holds, incomplete spatial coverage, complex planning and acquisition, low scan efficiency and long scan times.
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