Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Objective: We aimed to describe management of biliary obstruction (BO) in the context of pancreatic cancer within a population-based cohort.

Methods: We examined management of BO in 1863 patients diagnosed as having pancreatic cancer in 2010/2011. We used descriptive statistics and logistic regression to describe patterns of biliary stent usage, complications and duration of patency, associations between preoperative stenting and surgical outcomes, and between patient factors and management of jaundice.

Results: Almost half of the people in the cohort (n = 909) were jaundiced within 12 months of diagnosis. Two-thirds of these had at least 1 stent inserted. Preoperative stenting, mostly with plastic stents, occurred for 72% of patients who experienced jaundice prior to an attempted resection but was not associated with surgical outcomes. Seventy percent of the jaundiced patients who did not have an attempted resection were stented. Metal stents were less frequently replaced within 30 days than plastic (9% vs 42%). Living in a rural area was associated with reduced likelihood of having jaundice managed.

Conclusions: Plastic stents were still used frequently, despite guidelines recommending metal in most contexts. Patients living in rural areas were less likely to have BO managed. This work highlights the need to monitor current practice.

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPA.0000000000000960DOI Listing

Publication Analysis

Top Keywords

pancreatic cancer
12
cancer population-based
8
preoperative stenting
8
surgical outcomes
8
plastic stents
8
attempted resection
8
stents frequently
8
living rural
8
patients
5
biliary stenting
4

Similar Publications

Background: Prior studies have implicated diabetes as a risk factor for pancreatic cancer, yet the impact of diabetes progression on pancreatic cancer incidence remains unclear. We aim to assess pancreatic cancer risk across different stages of diabetes.

Methods: Employing a predefined search strategy, we conducted a literature review of electronic databases up to 29 February 2024.

View Article and Find Full Text PDF

Purpose: To assess modified folinic acid/leucovorin, fluorouracil, irinotecan, oxaliplatin (FOLFIRINOX; mFFX) versus gemcitabine/nab-paclitaxel (GnP) in de novo metastatic pancreatic ductal adenocarcinoma (PDAC) and explore predictive biomarkers.

Patients And Methods: Patients were randomly assigned 1:1 to mFFX or GnP with exclusion of germline pathogenic variants in or . The primary end point was progression-free survival (PFS) between arms with 0.

View Article and Find Full Text PDF

Objective: To evaluate the burden and trends of digestive system cancers in adolescents and young adults (AYAs) globally between 1990 and 2021.

Methods: Data were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (1990-2021). We analyzed global, regional, and national disease burdens by calculating the age-standardized incidence (ASIR), mortality (ASMR), and disability-adjusted life years (DALYs) for AYAs.

View Article and Find Full Text PDF

Intravoxel Incoherent Motion (IVIM) MRI is a contrast-agent-free microvascular imaging method finding increasing use in biomedicine. However, there is uncertainty in the ability of IVIM-MRI to quantify tissue microvasculature given MRI's limited spatial resolution (mm scale). Nine NRG mice were subcutaneously inoculated with human pancreatic cancer BxPC-3 cells transfected with DsRed, and MR-compatible plastic window chambers were surgically installed in the dorsal skinfold.

View Article and Find Full Text PDF