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Herein, a novel ferrocene-rhodamine receptor conjugated with an allylimine bridge was facilely synthesized. This triple channel receptor can selectively and sensitively monitor Pd ions through chromogenic, fluorogenic and electrochemical assays in aqueous medium with a low detection limit (8.46 × 10 M) and a fast response (<8 min). It can be applied as a fluorescent probe for effective survey of Pd ions in living cells. Moreover, a plausible recognition mode was proposed and rationalized by theoretical calculations.
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http://dx.doi.org/10.1039/c7an01505d | DOI Listing |
Anal Chem
September 2025
Anhui Key Laboratory of Biomedical Materials and Chemical Measurement, Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P.R. China.
Current colorimetric sensing arrays for antioxidant detection often struggle with discrimination due to cross-reactive signals from individual nanozymes. These signals are typically modulated by external factors such as pH or chromogenic substrates, offering limited kinetic and mechanistic diversity. To overcome this, we present a novel triple-channel colorimetric sensing array utilizing two distinct single-atom nanozymes (Cu SA and Fe SA) and one dual-atom nanozyme (CuFe DA).
View Article and Find Full Text PDFUnlabelled: Triple-negative breast cancer (TNBC) remains a significant clinical challenge due to its aggressive nature and lack of effective targeted therapies. The enzyme ceramide synthase 2 (CerS2), which synthesizes pro-apoptotic very long-chain ceramides (VLCCs), represents a promising therapeutic target. Here, we identify and characterize DH20931, a novel, first-in-class small-molecule agonist of CerS2.
View Article and Find Full Text PDFSci Rep
September 2025
Sanko School, Gaziantep, Turkey.
This study presents a novel privacy-preserving deep learning framework for accurately classifying fine-grained hygiene and water-usage events in restroom environments. Leveraging a comprehensive, curated dataset comprising approximately 460 min of stereo audio recordings from five acoustically diverse bathrooms, our method robustly identifies 11 distinct events, including nuanced variations in faucet counts and flow rates, toilet flushing, and handwashing activities. Stereo audio inputs were transformed into triple-channel Mel spectrograms using an adaptive one-dimensional convolutional neural network (1D-CNN), dynamically synthesizing spatial cues to enhance discriminative power.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
August 2025
Key Laboratory of Acupuncture-Moxibustion and Tuina Intelligent Equipment of Chongqing Administration of Traditional Chinese Medicine, School of Pharmacy, Chongqing Three Gorges Medical College, Chongqing 404120, PR China. Electronic address:
Water monitoring in organic solvents is crucial but remains challenging. Karl Fischer titration can reach ∼1 ppm but relies on toxic reagents and bench-top equipment; most fluorescent probes, in contrast, cover <10 % (v/v) water and provide only a single read-out. Here we introduce two triphenylamine functionalized hydrazone probes, DHB and DHF, that overcome these limitations by simultaneously translating water stimuli into three independent, quantitative fluorescence signals-wavelength, intensity and RGB color-within a single measurement.
View Article and Find Full Text PDFLancet
August 2025
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia. Electronic address:
Background: We aimed to quantify the blood pressure-lowering efficacy of antihypertensive drugs and their combinations from the five major drug classes.
Methods: We conducted a systematic review and meta-analysis of randomised, double-blind, placebo-controlled trials involving adult participants randomly assigned to receive angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, β blockers, calcium channel blockers, or diuretics. Eligibility criteria included follow-up duration between 4 weeks and 26 weeks, antihypertensive drug treatment fixed in all participants for at least 4 weeks before follow-up blood pressure assessment; and availability of clinic blood pressure for the calculation of mean difference in systolic blood pressure between treatment groups.