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The associations between number and space have been intensively investigated. Recent studies indicated that this association could extend to more complex tasks, such as mental arithmetic. However, the mechanism of arithmetic-space associations in mental arithmetic was still a topic of debate. Thus, in the current study, we adopted an eye-tracking technology to investigate whether spatial bias induced by mental arithmetic was related with spatial attention shifts on the mental number line or with semantic link between the operator and space. In Experiment 1, participants moved their eyes to the corresponding response area according to the cues after solving addition and subtraction problems. The results showed that the participants moved their eyes faster to the leftward space after solving subtraction problems and faster to the right after solving addition problems. However, there was no spatial bias observed when the second operand was zero in the same time window, which indicated that the emergence of spatial bias may be associated with spatial attention shifts on the mental number line. In Experiment 2, participants responded to the operator (operation plus and operation minus) with their eyes. The results showed that mere presentation of operator did not cause spatial bias. Therefore, the arithmetic-space associations might be related with the movement along the mental number line.
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http://dx.doi.org/10.1177/0301006617738718 | DOI Listing |
Acta Pharmacol Sin
September 2025
Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Bas
Recent investigations into the rapid antidepressant effects of ketamine, along with studies on schizophrenia-related susceptibility genes, have highlighted the GluN2A subunit as a critical regulator of both emotion and cognition. However, the specific impacts of acute pharmacological inhibition of GluN2A-containing NMDA receptors on brain microcircuits and the subsequent behavioral consequences remain poorly understood. In this study, we first examined the effects of MPX-004, a selective GluN2A NMDA receptor inhibitor, on behavior within the dorsomedial prefrontal cortex (dmPFC).
View Article and Find Full Text PDFCereb Cortex
August 2025
Department of Psychology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unilateral CI use in the first and seventh months after CI activation using speech comprehension measures and electroencephalography recordings, both during passive listening and an active spatial listening task.
View Article and Find Full Text PDFInt J Surg
September 2025
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Background: Precise acetabular cup placement in total hip arthroplasty (THA) heavily relies on surgeons' visual judgment of angles. However, whether inherent visual angle misperception among surgeons affects surgical outcomes remains unclear. This study is the first to reveal that surgeons universally exhibit visual angle misperception, a key factor causing the cup implant positioning deviations in THA.
View Article and Find Full Text PDFFront Neurosci
August 2025
Acoustics Research Institute, Austrian Academy of Sciences, Vienna, Austria.
Introduction: Spatial hearing enables both voluntary localization of sound sources and automatic monitoring of the surroundings. The auditory looming bias (ALB), characterized by the prioritized processing of approaching (looming) sounds over receding ones, is thought to serve as an early hazard detection mechanism. The bias could theoretically reflect an adaptation to the low-level acoustic properties of approaching sounds, or alternatively necessitate the sound to be localizable in space.
View Article and Find Full Text PDFHandb Exp Pharmacol
September 2025
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
GPCRs are known for their versatile signaling roles at the plasma membrane; however, recent studies have revealed that these receptors also function within various intracellular compartments, such as endosomes, the Golgi apparatus, and the endoplasmic reticulum. This spatially distinct signaling, termed location bias, allows GPCRs to initiate unique signaling cascades and influence cellular processes-including cAMP production, calcium mobilization, and protein phosphorylation-in a compartment-specific manner. By mapping the impact of GPCR signaling from these subcellular locations, this chapter emphasizes the mechanisms underlying signaling from intracellular receptor pools in diversifying receptor functionality.
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