Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Functional lateralization can be an indicator of brain maturation. We have consistently shown that, in the adult brain, proprioceptive processing of muscle spindle afferents generating illusory movement of the right hand activates inferior frontoparietal cortical regions in a right-side dominant manner in addition to the cerebrocerebellar motor network. Here we provide novel evidence regarding the development of the right-dominant use of the inferior frontoparietal cortical regions in humans using this task. We studied brain activity using functional magnetic resonance imaging while 60 right-handed blindfolded healthy children (8-11 years), adolescents (12-15 years), and young adults (18-23 years) (20 per group) experienced the illusion. Adult-like right-dominant use of the inferior parietal lobule (IPL) was observed in adolescents, while children used the IPL bilaterally. In contrast, adult-like lateralized cerebrocerebellar motor activation patterns were already observable in children. The right-side dominance progresses during adolescence along with the suppression of the left-sided IPL activity that emerges during childhood. Therefore, the neuronal processing implemented in the adult's right IPL during the proprioceptive illusion task is likely mediated bilaterally during childhood, and then becomes right-lateralized during adolescence at a substantially later time than the lateralized use of the cerebrocerebellar motor system for kinesthetic processing.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939204 | PMC |
| http://dx.doi.org/10.1093/cercor/bhx223 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation.
J Integr Neurosci
June 2025
Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.
Background: It has been demonstrated that the cerebellum plays a critical role not only in motor function but also in cognitive function. Numerous studies have revealed that acute sleep deprivation (SD) alters the functional connectivity (FC) in the cerebral cortex associated with declining working memory (WM). However, the relationship between the altered cerebro-cerebellar FC and white matter damage following acute sleep deprivation remains elusive.
View Article and Find Full Text PDFCerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action.
Cerebellum
June 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
The motor learning theory anticipates that cerebro-cerebellar loops perform sensorimotor prediction, thereby regulating motor control during action execution (AE) and observation (AO), but the causal interaction between the cerebellum and cerebral cortex remains unclear. Therefore, our aim was to understand what triggers neuronal activity between brain areas engaged in a visuo-motor task that involves cortico-cerebellar interactions, organised in loops. We used Dynamic Causal Modelling (DCM) to study functional MRI (fMRI) data obtained in healthy participants during a squeeze-ball task in either execution or observation conditions.
View Article and Find Full Text PDFThe Cerebellum as a Predictor: Recent Insights Into Cognitive Control and Extension of Kalman Filter Theory to Cognition.
Discov Med
May 2025
Service de Neurologie, Médiathèque Jean Jacquy, CHU-Charleroi, 6000 Charleroi, Belgium.
Traditionally viewed as a motor control center, the cerebellum is increasingly recognized as a crucial component of a neural network that enables adaptive behavior across various domains, including cognition, affect, emotion, and social interactions. Recent clinical studies have linked cerebellar dysfunction to impairments in mentalizing and narrative coherence in autism spectrum disorder (ASD). Given that narratives involve the temporal sequencing of causally related events and actions, these findings imply the potential role of the cerebellum in predictive sequence.
View Article and Find Full Text PDFCerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration.
J Neurol
March 2025
Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Room 5.43, Pearse Street, Dublin 2, Ireland.
Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share overlapping clinical, genetic, and neuroimaging features; a spectrum of conditions commonly referred to as the ALS-FTD continuum. The majority of imaging studies focus on supratentorial pathology, and phenotype-defining motor, cognitive, and behavioural profiles are often exclusively attributed to supratentorial degeneration overlooking the contribution of cerebellar pathology.
Methods: A multimodal neuroimaging study was conducted to evaluate phenotype-associated cerebello-cerebral connectivity profiles in ALS-FTD, behavioural variant frontotemporal dementia (bvFTD), non-fluent variant (nfvPPA), and semantic variant primary progressive aphasia (svPPA).
Age-related differences in task-related modulation of cerebellar brain inhibition.
Neurobiol Aging
June 2025
Neuroplasticity and Movement Control Research Group, Rehabilitation Research Institute, Hasselt University, Diepenbeek, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium; Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences,
Age-related reductions in cerebellar integrity predict motor impairments in older adults (OA), but the contribution of cerebro-cerebellar interactions to these impairments remains unclear. Understanding these interactions could reveal underlying mechanisms associated with age-related deficits in motor control. To explore this, twenty younger adults (YA) and twenty OA, all right-handed, participated in a dual-site transcranial magnetic stimulation protocol.
View Article and Find Full Text PDF