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A tone-scramble is a rapid, randomly ordered sequence of pure tones. Chubb, Dickson, Dean, Fagan, Mann, Wright, Guan, Silva, Gregersen, and Kowalski [(2013). J. Acoust. Soc. Am. 134(4), 3067-3078] showed that a task requiring listeners to classify major vs minor tone-scrambles yielded a strikingly bimodal distribution. The current study sought to clarify the nature of the skill required in this task. In each of the "semitone" tasks, all tone-scrambles contained eight each of the notes G, D, and G (to establish G as the tonic) and eight copies of a target note. The target note was either A♭ or A in the "2" task, B♭ or B in the "3" task, C or D♭ in the "4" task, E♭ or E in the "6" task, and F or G♭ in the "7" task. On each trial, the listener strove to classify each stimulus according to its target note. Performance was best (and nearly equal) in the 2, 3, and 6 tasks, intermediate in the 4 task and worst in the 7 task. The results were well-described by a model in which a single cognitive resource controls performance in all five semitone tasks. This resource is called "scale sensitivity" here because it seems to confer general sensitivity to variations in scale in the presence of a fixed tonic.
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http://dx.doi.org/10.1121/1.4998572 | DOI Listing |
Cureus
August 2025
Orthopedic Surgery, Sudan Medical Specialization Board, Wad Madani, SDN.
Background: High-quality operative notes are crucial for patient safety, continuity of care, and medico-legal protection. Despite established Royal College of Surgeons (RCS) guidelines, audits globally reveal persistent deficiencies in surgical documentation. This study assessed the quality of operative notes in the Orthopedic Surgery Department at Gezira Traumatology Center, Wad Madani Teaching Hospital, Sudan, and evaluated the impact of targeted interventions.
View Article and Find Full Text PDFFront Immunol
September 2025
Immunocore Ltd., Abingdon, United Kingdom.
Background: The programmed cell death protein 1 (PDCD1 or PD-1) is a key regulatory immune checkpoint and a major target for therapeutic intervention. In oncology, antibodies blocking the PD-1 pathway are used to activate immune cells to promote anti tumour immunity while in immune-mediated inflammatory diseases, PD-1 agonist molecules have the potential to achieve immune suppression. NK cells are a specialised population of innate lymphocytes able to recognize a large range of distressed cells including damaged tissues in autoimmune and inflammatory conditions.
View Article and Find Full Text PDFFront Public Health
September 2025
Neurosciences Axis, Centre de Recherche du Centre Hospitalier Universitaire (CRCHU) de Québec-Université Laval, Québec City, QC, Canada.
Introduction: Preventive measures have been implemented in hospitals during COVID-19, but how these guidelines affected mental health among healthcare workers (HCWs) remains to be determined. On another note, reliable psychological and blood-based markers are needed to promptly identify HCWs at-risk to develop distress. Extracellular vesicles (EVs) originating from brain cross the blood-brain barrier and are detectable in blood, giving them a highly valuable potential for biomarker discovery.
View Article and Find Full Text PDFHeart Lung Circ
September 2025
Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; Department of Cardiology, Central Adelaide Local Health Network, Adelaide, SA,
Cardiovascular-kidney-metabolic (CKM) syndrome is a term that is increasingly used to describe interconnected conditions that lead to poor health outcomes, including cardiovascular disease, chronic kidney disease, type 2 diabetes, and obesity. Historically, there have been very few targeted pharmacotherapies available that have changed cardiovascular outcomes for people with CKM syndromes; however, over the past decade, new pharmacologic options have rapidly expanded, with strong evidence for cardiovascular and kidney protective benefits in CKM conditions. Of note, sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists have emerged as key therapeutic options and are now widely guideline-endorsed.
View Article and Find Full Text PDFJ Nephrol
September 2025
Italian Society of General Medicine (SIMG), COMEGEN Primary Care Physicians Cooperative, Naples, Italy.
Background: Kidney stone formation is driven by an imbalance between lithogenic substances and crystallization inhibitors. Current guidelines recommend a 24-h urine collection in patients with kidney stone disease to assess the risk of stone formation and monitor therapy compliance. However, real-world data on adherence to these guidelines remain limited and outdated.
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