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| http://dx.doi.org/10.1016/j.clim.2017.09.011 | DOI Listing |
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Fatal Toxoplasma gondii COUG strain infections in southern sea otters (Enhydra lutris nereis): New insight on contributing factors and parasite serotyping.
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Fatal infections with the rare COUG strain of the zoonotic parasite Toxoplasma gondii were recently detected for the first time in four southern sea otters (Enhydra lutris nereis) exhibiting severe protozoal steatitis. The objectives of this study were to describe new COUG strain infections in sea otters, investigate the potential contributory role of a recently discovered parasite-infecting narnavirus (Apocryptovirus odysseus) in these infections, assess the potential contribution of vitamin E deficiency in the development of systemic steatitis, and explore the utility of serotyping for strain-specific diagnosis of T. gondii infections in sea otters.
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Toxoplasma gondii is a significant pathogen in both humans and animals, with disease progression driven by the rapid proliferation of its tachyzoite stage. In this study, we identify the PP2A-2 holoenzyme as a key regulator of daughter cell emergence during parasite division. This holoenzyme, likely composed of the regulatory subunit TgPR48 (PP2A-B2), the catalytic subunit PP2A-C2, and the scaffolding subunit PP2A-A2, is essential for proper cytokinesis.
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, responsible for toxoplasmosis, is one of the worldwide prevalent parasitic zoonoses infecting warm-blooded animals including humans with cats being the definitive host. Congenital transmission can occur and leads to congenital toxoplasmosis, which may result in foetal or neonatal death, or severe malformations. In this study, we aimed to determine the seroprevalence and associated factors among pregnant women in a rural setting of Burkina Faso.
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